Kidney impairment in fetal growth restriction : three-dimensional evaluation of volume and vascularization
© 2020 John Wiley & Sons, Ltd..
OBJECTIVES: Renal development is impaired in fetal growth restriction (FGR). Renal size can be considered a surrogate of renal function in childhood, and could be impaired in that condition. Our aim was to evaluate the ratio of total renal volume, measured by three-dimensional ultrasound, to estimated fetal weight (TRV/EFW) among fetuses with and without growth restriction. Furthermore, we correlated TRV/EFW with fetal Doppler velocimetry and renal vascularization indexes and evaluated the association of renal volume and vascular parameters with adverse neonatal events in growth-restricted fetuses.
METHODS: In a retrospective cohort, TRV and renal vascularization of growth-restricted and normal fetuses were evaluated by three-dimensional ultrasonography and VOCAL technique. Independent samples t-tests and Mann-Whitney test were used for comparisons between groups. Logistic regression model was applied to evaluate the association between renal characteristics and adverse neonatal events.
RESULTS: Seventy-one growth-restricted fetuses were compared to 194 controls. The TRV/EFW was lower in the growth-restricted group (P < .001). In our sample, this ratio did not correlate with Doppler velocimetry parameters, renal vascular indexes or any adverse neonatal events.
CONCLUSION: The TRV/EFW ratio is decreased in FGR. Further studies are needed to investigate the association of this ratio with long-term renal outcomes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
Prenatal diagnosis - 40(2020), 11 vom: 15. Okt., Seite 1408-1417 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Senra, Janaína Campos [VerfasserIn] |
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| Anmerkungen: |
Date Completed 20.10.2021 Date Revised 20.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/pd.5778 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM311622380 |
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| 500 | |a Date Completed 20.10.2021 | ||
| 500 | |a Date Revised 20.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 John Wiley & Sons, Ltd. | ||
| 520 | |a OBJECTIVES: Renal development is impaired in fetal growth restriction (FGR). Renal size can be considered a surrogate of renal function in childhood, and could be impaired in that condition. Our aim was to evaluate the ratio of total renal volume, measured by three-dimensional ultrasound, to estimated fetal weight (TRV/EFW) among fetuses with and without growth restriction. Furthermore, we correlated TRV/EFW with fetal Doppler velocimetry and renal vascularization indexes and evaluated the association of renal volume and vascular parameters with adverse neonatal events in growth-restricted fetuses | ||
| 520 | |a METHODS: In a retrospective cohort, TRV and renal vascularization of growth-restricted and normal fetuses were evaluated by three-dimensional ultrasonography and VOCAL technique. Independent samples t-tests and Mann-Whitney test were used for comparisons between groups. Logistic regression model was applied to evaluate the association between renal characteristics and adverse neonatal events | ||
| 520 | |a RESULTS: Seventy-one growth-restricted fetuses were compared to 194 controls. The TRV/EFW was lower in the growth-restricted group (P < .001). In our sample, this ratio did not correlate with Doppler velocimetry parameters, renal vascular indexes or any adverse neonatal events | ||
| 520 | |a CONCLUSION: The TRV/EFW ratio is decreased in FGR. Further studies are needed to investigate the association of this ratio with long-term renal outcomes | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Yoshizaki, Carlos Tadashi |e verfasserin |4 aut | |
| 700 | 1 | |a Doro, Giovana Farina |e verfasserin |4 aut | |
| 700 | 1 | |a Ruano, Rodrigo |e verfasserin |4 aut | |
| 700 | 1 | |a Gibelli, Maria Augusta Bento Cicaroni |e verfasserin |4 aut | |
| 700 | 1 | |a Rodrigues, Agatha Sacramento |e verfasserin |4 aut | |
| 700 | 1 | |a Koch, Vera Hermina Kalika |e verfasserin |4 aut | |
| 700 | 1 | |a Krebs, Vera Lúcia Jornada |e verfasserin |4 aut | |
| 700 | 1 | |a Zugaib, Marcelo |e verfasserin |4 aut | |
| 700 | 1 | |a Francisco, Rossana Pulcineli Vieira |e verfasserin |4 aut | |
| 700 | 1 | |a Bernardes, Lisandra Stein |e verfasserin |4 aut | |
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