Risk factors for disease progression in COVID-19 patients
BACKGROUND: Coronavirus disease (COVID-19) is rapidly spreading worldwide. Although 10-20% of patients with COVID-19 have severe symptoms, little is known about the risk factors related to the aggravation of COVID-19 symptoms from asymptomatic or mild to severe disease states.
METHODS: This retrospective study included 211 patients who were asymptomatic or with mild presentations of COVID-19. We evaluated the differences in demographic and clinical data between the cured (discharged to home) and transferred (aggravated to severe-stage COVID-19) groups.
RESULTS: A multivariate logistic analysis showed that body temperature, chills, initial chest X-ray findings, and the presence of diabetes were significantly associated with predicting the progression to severe stage of COVID-19 (p < 0.05). The odds ratio of transfer in patients with COVID-19 increased by 12.7-fold for abnormal findings such as haziness or consolidation in initial chest X-ray, 6.32-fold for initial symptom of chills, and 64.1-fold for diabetes.
CONCLUSIONS: Even if patients are asymptomatic or have mild symptoms, clinicians should closely observe patients with COVID-19 presenting with chills, body temperature > 37.5 °C, findings of pneumonia in chest X-ray, or diabetes.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2020 |
---|---|
Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
---|---|
Enthalten in: |
BMC infectious diseases - 20(2020), 1 vom: 23. Juni, Seite 445 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Chang, Min Cheol [VerfasserIn] |
---|
Links: |
---|
Themen: |
Chilling |
---|
Anmerkungen: |
Date Completed 29.06.2020 Date Revised 18.12.2020 published: Electronic Citation Status MEDLINE |
---|
doi: |
10.1186/s12879-020-05144-x |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM311546196 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM311546196 | ||
003 | DE-627 | ||
005 | 20231225142502.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2020 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1186/s12879-020-05144-x |2 doi | |
028 | 5 | 2 | |a pubmed24n1038.xml |
035 | |a (DE-627)NLM311546196 | ||
035 | |a (NLM)32576139 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Chang, Min Cheol |e verfasserin |4 aut | |
245 | 1 | 0 | |a Risk factors for disease progression in COVID-19 patients |
264 | 1 | |c 2020 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 29.06.2020 | ||
500 | |a Date Revised 18.12.2020 | ||
500 | |a published: Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a BACKGROUND: Coronavirus disease (COVID-19) is rapidly spreading worldwide. Although 10-20% of patients with COVID-19 have severe symptoms, little is known about the risk factors related to the aggravation of COVID-19 symptoms from asymptomatic or mild to severe disease states | ||
520 | |a METHODS: This retrospective study included 211 patients who were asymptomatic or with mild presentations of COVID-19. We evaluated the differences in demographic and clinical data between the cured (discharged to home) and transferred (aggravated to severe-stage COVID-19) groups | ||
520 | |a RESULTS: A multivariate logistic analysis showed that body temperature, chills, initial chest X-ray findings, and the presence of diabetes were significantly associated with predicting the progression to severe stage of COVID-19 (p < 0.05). The odds ratio of transfer in patients with COVID-19 increased by 12.7-fold for abnormal findings such as haziness or consolidation in initial chest X-ray, 6.32-fold for initial symptom of chills, and 64.1-fold for diabetes | ||
520 | |a CONCLUSIONS: Even if patients are asymptomatic or have mild symptoms, clinicians should closely observe patients with COVID-19 presenting with chills, body temperature > 37.5 °C, findings of pneumonia in chest X-ray, or diabetes | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Chilling | |
650 | 4 | |a Coronavirus disease | |
650 | 4 | |a Diabetes | |
650 | 4 | |a Fever | |
650 | 4 | |a Risk factor: symptom aggravation | |
700 | 1 | |a Park, Yu-Kyung |e verfasserin |4 aut | |
700 | 1 | |a Kim, Bong-Ok |e verfasserin |4 aut | |
700 | 1 | |a Park, Donghwi |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t BMC infectious diseases |d 2001 |g 20(2020), 1 vom: 23. Juni, Seite 445 |w (DE-627)NLM11120089X |x 1471-2334 |7 nnns |
773 | 1 | 8 | |g volume:20 |g year:2020 |g number:1 |g day:23 |g month:06 |g pages:445 |
856 | 4 | 0 | |u http://dx.doi.org/10.1186/s12879-020-05144-x |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 20 |j 2020 |e 1 |b 23 |c 06 |h 445 |