Risk factors for disease progression in COVID-19 patients

BACKGROUND: Coronavirus disease (COVID-19) is rapidly spreading worldwide. Although 10-20% of patients with COVID-19 have severe symptoms, little is known about the risk factors related to the aggravation of COVID-19 symptoms from asymptomatic or mild to severe disease states.

METHODS: This retrospective study included 211 patients who were asymptomatic or with mild presentations of COVID-19. We evaluated the differences in demographic and clinical data between the cured (discharged to home) and transferred (aggravated to severe-stage COVID-19) groups.

RESULTS: A multivariate logistic analysis showed that body temperature, chills, initial chest X-ray findings, and the presence of diabetes were significantly associated with predicting the progression to severe stage of COVID-19 (p < 0.05). The odds ratio of transfer in patients with COVID-19 increased by 12.7-fold for abnormal findings such as haziness or consolidation in initial chest X-ray, 6.32-fold for initial symptom of chills, and 64.1-fold for diabetes.

CONCLUSIONS: Even if patients are asymptomatic or have mild symptoms, clinicians should closely observe patients with COVID-19 presenting with chills, body temperature > 37.5 °C, findings of pneumonia in chest X-ray, or diabetes.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:20

Enthalten in:

BMC infectious diseases - 20(2020), 1 vom: 23. Juni, Seite 445

Sprache:

Englisch

Beteiligte Personen:

Chang, Min Cheol [VerfasserIn]
Park, Yu-Kyung [VerfasserIn]
Kim, Bong-Ok [VerfasserIn]
Park, Donghwi [VerfasserIn]

Links:

Volltext

Themen:

Chilling
Coronavirus disease
Diabetes
Fever
Journal Article
Risk factor: symptom aggravation

Anmerkungen:

Date Completed 29.06.2020

Date Revised 18.12.2020

published: Electronic

Citation Status MEDLINE

doi:

10.1186/s12879-020-05144-x

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM311546196