Screening of Mothers in a COVID-19 Low-Prevalence Region : Determination of SARS-CoV-2 Antibodies in 401 Mothers from Rostock by ELISA and Confirmation by Immunofluorescence
© Georg Thieme Verlag KG Stuttgart · New York..
BACKGROUND: In children, the infection with SARS-CoV-2, the cause of COVID-19, tends to be clinically inapparent more often or less severe than in adults. The spread of this infection from children poses a danger to vulnerable adults. Therefore, child care institutions and schools currently are widely closed.
METHODS: Since the status of infection tends to be congruent in mothers and their children, we tested 401 mothers of children between 1 and 10 years in the city of Rostock (State of Mecklenburg-Westpomerania, northeast of Germany), for the presence of RNA of SARS-CoV-2 in throat swabs, and of antibodies against SARS-CoV-2 in serum.
RESULTS: In none of the mothers tested, RNA of this virus was detected in the throat swab. In the ELISA test, IgG antibodies were positive in one serum sample, IgA antibodies were positive in 11, and borderline in 3 serum samples. All 401 sera were negative in the indirect immunofluorescence test (IIFT) with FITC-labeled IgG, IgA, und IgM antibodies.
CONCLUSION: At the time of this study, neither SARS-CoV-2 RNA, nor specific antibodies against SARS-CoV-2 were detectable in the mothers tested in Rostock.
| Errataetall: |
CommentIn: Dtsch Med Wochenschr. 2020 Oct;145(21):1580-1581. - PMID 32957150 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:145 |
|---|---|
| Enthalten in: |
Deutsche medizinische Wochenschrift (1946) - 145(2020), 17 vom: 01. Aug., Seite e96-e100 |
| Sprache: |
Deutsch |
|---|
| Weiterer Titel: |
Mütter-Screening in einem COVID-19-Niedrig-Pandemiegebiet: Bestimmung SARS-CoV-2-spezifischer Antikörper bei 401 Rostocker Müttern mittels ELISA und Immunfluoreszenz-Bestätigungstest |
|---|
| Beteiligte Personen: |
Reisinger, Emil C [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 03.09.2020 Date Revised 29.03.2024 published: Print-Electronic CommentIn: Dtsch Med Wochenschr. 2020 Oct;145(21):1580-1581. - PMID 32957150 Citation Status MEDLINE |
|---|
| doi: |
10.1055/a-1197-4293 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM311514006 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM311514006 | ||
| 003 | DE-627 | ||
| 005 | 20240329233010.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||ger c | ||
| 024 | 7 | |a 10.1055/a-1197-4293 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1354.xml |
| 035 | |a (DE-627)NLM311514006 | ||
| 035 | |a (NLM)32572869 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a ger | ||
| 100 | 1 | |a Reisinger, Emil C |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Screening of Mothers in a COVID-19 Low-Prevalence Region |b Determination of SARS-CoV-2 Antibodies in 401 Mothers from Rostock by ELISA and Confirmation by Immunofluorescence |
| 246 | 3 | 3 | |a Mütter-Screening in einem COVID-19-Niedrig-Pandemiegebiet: Bestimmung SARS-CoV-2-spezifischer Antikörper bei 401 Rostocker Müttern mittels ELISA und Immunfluoreszenz-Bestätigungstest |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 03.09.2020 | ||
| 500 | |a Date Revised 29.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Dtsch Med Wochenschr. 2020 Oct;145(21):1580-1581. - PMID 32957150 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Georg Thieme Verlag KG Stuttgart · New York. | ||
| 520 | |a BACKGROUND: In children, the infection with SARS-CoV-2, the cause of COVID-19, tends to be clinically inapparent more often or less severe than in adults. The spread of this infection from children poses a danger to vulnerable adults. Therefore, child care institutions and schools currently are widely closed | ||
| 520 | |a METHODS: Since the status of infection tends to be congruent in mothers and their children, we tested 401 mothers of children between 1 and 10 years in the city of Rostock (State of Mecklenburg-Westpomerania, northeast of Germany), for the presence of RNA of SARS-CoV-2 in throat swabs, and of antibodies against SARS-CoV-2 in serum | ||
| 520 | |a RESULTS: In none of the mothers tested, RNA of this virus was detected in the throat swab. In the ELISA test, IgG antibodies were positive in one serum sample, IgA antibodies were positive in 11, and borderline in 3 serum samples. All 401 sera were negative in the indirect immunofluorescence test (IIFT) with FITC-labeled IgG, IgA, und IgM antibodies | ||
| 520 | |a CONCLUSION: At the time of this study, neither SARS-CoV-2 RNA, nor specific antibodies against SARS-CoV-2 were detectable in the mothers tested in Rostock | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Antibodies, Viral |2 NLM | |
| 650 | 7 | |a RNA, Viral |2 NLM | |
| 700 | 1 | |a von Possel, Ronald |e verfasserin |4 aut | |
| 700 | 1 | |a Warnke, Philipp |e verfasserin |4 aut | |
| 700 | 1 | |a Geerdes-Fenge, Hilte F |e verfasserin |4 aut | |
| 700 | 1 | |a Hemmer, Christoph J |e verfasserin |4 aut | |
| 700 | 1 | |a Pfefferle, Susanne |e verfasserin |4 aut | |
| 700 | 1 | |a Löbermann, Micha |e verfasserin |4 aut | |
| 700 | 1 | |a Littmann, Martina |e verfasserin |4 aut | |
| 700 | 1 | |a Emmerich, Petra |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Deutsche medizinische Wochenschrift (1946) |d 1946 |g 145(2020), 17 vom: 01. Aug., Seite e96-e100 |w (DE-627)NLM000002852 |x 1439-4413 |7 nnns |
| 773 | 1 | 8 | |g volume:145 |g year:2020 |g number:17 |g day:01 |g month:08 |g pages:e96-e100 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1055/a-1197-4293 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 145 |j 2020 |e 17 |b 01 |c 08 |h e96-e100 | ||