Identification of the association of CD28+ CD244+ Tc17/IFN-γ cells with chronic hepatitis C virus infection
© 2020 Wiley Periodicals LLC..
CD8+ T cells play multiple and complex immunological roles including antiviral, regulatory, and exhaustive effects in hepatitis C virus (HCV) infected patients. Some CD8+ T-cell subsets were confirmed to be closely related to HCV infection such as TCM , TEM , TEM RA, Tc17, and CD8+ Treg. Herein, we report a new subset of interleukin (IL)-17/interferon (IFN)-γ producing CD8+ T (Tc17/IFN-γ) cells that markedly correlate with CD28+ CD244+ cells, IL-17 levels, and HCV RNA in HCV patients. During early treatment with peg-IFN-a2a plus ribavirin, the imbalance of these Tc17/IFN-γ cells could be partially restored, together with normalized serum alanine aminotransferase but not aspartate transaminase. Also, we analyzed the dynamic change of the percentage of this T cells subset in patients with different outcome after 4-week course of treatment with peg-IFN-a2a plus ribavirin and found that the percentage of CD8+ CD28+ CD244+ T cells significantly decreased in recovered patients but not in nonrecovered patients. In vitro, CD28+ CD244+ T cells were the only CD8+ T-cell group that secreted both IL-17 and IFN-γ in this axis and blockade with anti-CD244 antibodies significantly reduced cytokine production. Taken together, this study demonstrates that the frequency and regulatory functions of CD28+ CD244+ Tc17/IFN-γ cells may play an important role in persistent HCV infection.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:92 |
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| Enthalten in: |
Journal of medical virology - 92(2020), 12 vom: 01. Dez., Seite 3534-3544 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Han, Wenzheng [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 30.11.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1002/jmv.26205 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM311470262 |
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| 520 | |a © 2020 Wiley Periodicals LLC. | ||
| 520 | |a CD8+ T cells play multiple and complex immunological roles including antiviral, regulatory, and exhaustive effects in hepatitis C virus (HCV) infected patients. Some CD8+ T-cell subsets were confirmed to be closely related to HCV infection such as TCM , TEM , TEM RA, Tc17, and CD8+ Treg. Herein, we report a new subset of interleukin (IL)-17/interferon (IFN)-γ producing CD8+ T (Tc17/IFN-γ) cells that markedly correlate with CD28+ CD244+ cells, IL-17 levels, and HCV RNA in HCV patients. During early treatment with peg-IFN-a2a plus ribavirin, the imbalance of these Tc17/IFN-γ cells could be partially restored, together with normalized serum alanine aminotransferase but not aspartate transaminase. Also, we analyzed the dynamic change of the percentage of this T cells subset in patients with different outcome after 4-week course of treatment with peg-IFN-a2a plus ribavirin and found that the percentage of CD8+ CD28+ CD244+ T cells significantly decreased in recovered patients but not in nonrecovered patients. In vitro, CD28+ CD244+ T cells were the only CD8+ T-cell group that secreted both IL-17 and IFN-γ in this axis and blockade with anti-CD244 antibodies significantly reduced cytokine production. Taken together, this study demonstrates that the frequency and regulatory functions of CD28+ CD244+ Tc17/IFN-γ cells may play an important role in persistent HCV infection | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a CD244 | |
| 650 | 4 | |a CD28 | |
| 650 | 4 | |a HCV | |
| 650 | 4 | |a Tc17/IFN-γ cells | |
| 700 | 1 | |a Li, Jiajia |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Hongchang |e verfasserin |4 aut | |
| 700 | 1 | |a Qian, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Tong, Zhaowei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Weihong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhong, Jianfeng |e verfasserin |4 aut | |
| 700 | 1 | |a Xue, Tao |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Yao, Yunliang |e verfasserin |4 aut | |
| 700 | 1 | |a Shao, Shengwen |e verfasserin |4 aut | |
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