COVID-19 and the elderly : insights into pathogenesis and clinical decision-making
The elderly may represent a specific cluster of high-risk patients for developing COVID-19 with rapidly progressive clinical deterioration. Indeed, in older individuals, immunosenescence and comorbid disorders are more likely to promote viral-induced cytokine storm resulting in life-threatening respiratory failure and multisystemic involvement. Early diagnosis and individualized therapeutic management should be developed for elderly subjects based on personal medical history and polypharmacotherapy. Our review examines the pathogenesis and clinical implications of ageing in COVID-19 patients; finally, we discuss the evidence and controversies in the management in the long-stay residential care homes and aspects of end-of-life care for elderly patients with COVID-19.
| Errataetall: |
ErratumIn: Aging Clin Exp Res. 2020 Sep;32(9):1909. - PMID 32902821 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Aging clinical and experimental research - 32(2020), 8 vom: 18. Aug., Seite 1599-1608 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Perrotta, Fabio [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 Elderly patients |
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| Anmerkungen: |
Date Completed 03.09.2020 Date Revised 18.02.2022 published: Print-Electronic ErratumIn: Aging Clin Exp Res. 2020 Sep;32(9):1909. - PMID 32902821 Citation Status MEDLINE |
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| doi: |
10.1007/s40520-020-01631-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM311360181 |
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| 520 | |a The elderly may represent a specific cluster of high-risk patients for developing COVID-19 with rapidly progressive clinical deterioration. Indeed, in older individuals, immunosenescence and comorbid disorders are more likely to promote viral-induced cytokine storm resulting in life-threatening respiratory failure and multisystemic involvement. Early diagnosis and individualized therapeutic management should be developed for elderly subjects based on personal medical history and polypharmacotherapy. Our review examines the pathogenesis and clinical implications of ageing in COVID-19 patients; finally, we discuss the evidence and controversies in the management in the long-stay residential care homes and aspects of end-of-life care for elderly patients with COVID-19 | ||
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