False-positive reverse transcriptase polymerase chain reaction screening for SARS-CoV-2 in the setting of urgent head and neck surgery and otolaryngologic emergencies during the pandemic : Clinical implications
© 2020 Wiley Periodicals, Inc..
BACKGROUND: No reports describe falsepositive reverse transcriptase polymerase chain reaction (RT-PCR) for novel coronavirus in preoperative screening.
METHODS: Preoperative patients had one or two nasopharyngeal swabs, depending on low or high risk of viral transmission. Positive tests were repeated.
RESULTS: Forty-three of 52 patients required two or more preoperative tests. Four (9.3%) had discrepant results (positive/negative). One of these left the coronavirus disease (COVID) unit against medical advice despite an orbital abscess, with unknown true disease status. The remaining 3 of 42 (7.1%) had negative repeat RT-PCR. Although ultimately considered falsepositives, one was sent to a COVID unit postoperatively and two had urgent surgery delayed. Assuming negative repeat RT-PCR, clear chest imaging, and lack of subsequent symptoms represent the "gold standard," RT-PCR specificity was 0.97.
CONCLUSIONS: If false positives are suspected, we recommend computed tomography (CT) of the chest and repeat RT-PCR. Validated serum immunoglobulin testing may ultimately prove useful.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
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| Enthalten in: |
Head & neck - 42(2020), 7 vom: 07. Juli, Seite 1621-1628 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Katz, Andrew P [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 20.07.2020 Date Revised 18.12.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/hed.26317 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM311092950 |
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| 100 | 1 | |a Katz, Andrew P |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a False-positive reverse transcriptase polymerase chain reaction screening for SARS-CoV-2 in the setting of urgent head and neck surgery and otolaryngologic emergencies during the pandemic |b Clinical implications |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 20.07.2020 | ||
| 500 | |a Date Revised 18.12.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 Wiley Periodicals, Inc. | ||
| 520 | |a BACKGROUND: No reports describe falsepositive reverse transcriptase polymerase chain reaction (RT-PCR) for novel coronavirus in preoperative screening | ||
| 520 | |a METHODS: Preoperative patients had one or two nasopharyngeal swabs, depending on low or high risk of viral transmission. Positive tests were repeated | ||
| 520 | |a RESULTS: Forty-three of 52 patients required two or more preoperative tests. Four (9.3%) had discrepant results (positive/negative). One of these left the coronavirus disease (COVID) unit against medical advice despite an orbital abscess, with unknown true disease status. The remaining 3 of 42 (7.1%) had negative repeat RT-PCR. Although ultimately considered falsepositives, one was sent to a COVID unit postoperatively and two had urgent surgery delayed. Assuming negative repeat RT-PCR, clear chest imaging, and lack of subsequent symptoms represent the "gold standard," RT-PCR specificity was 0.97 | ||
| 520 | |a CONCLUSIONS: If false positives are suspected, we recommend computed tomography (CT) of the chest and repeat RT-PCR. Validated serum immunoglobulin testing may ultimately prove useful | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a RT-PCR | |
| 650 | 4 | |a head and neck surgery | |
| 650 | 4 | |a pandemic | |
| 650 | 4 | |a preoperative testing | |
| 650 | 7 | |a RNA, Viral |2 NLM | |
| 700 | 1 | |a Civantos, Francisco J |e verfasserin |4 aut | |
| 700 | 1 | |a Sargi, Zoukaa |e verfasserin |4 aut | |
| 700 | 1 | |a Leibowitz, Jason M |e verfasserin |4 aut | |
| 700 | 1 | |a Nicolli, Elizabeth A |e verfasserin |4 aut | |
| 700 | 1 | |a Weed, Donald |e verfasserin |4 aut | |
| 700 | 1 | |a Moskovitz, Alexander E |e verfasserin |4 aut | |
| 700 | 1 | |a Civantos, Alyssa M |e verfasserin |4 aut | |
| 700 | 1 | |a Andrews, David M |e verfasserin |4 aut | |
| 700 | 1 | |a Martinez, Octavio |e verfasserin |4 aut | |
| 700 | 1 | |a Thomas, Giovana R |e verfasserin |4 aut | |
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