Impact of Endoplasmic Reticulum Stress in Otorhinolaryngologic Diseases
The endoplasmic reticulum (ER) is an important organelle for normal cellular function and homeostasis in most living things. ER stress, which impairs ER function, occurs when the ER is overwhelmed by newly introduced immature proteins or when calcium in the ER is depleted. A number of diseases are associated with ER stress, including otorhinolaryngological diseases. The relationship between ER stress and otorhinolaryngologic conditions has been the subject of investigation over the last decade. Among otologic diseases associated with ER stress are otitis media and hearing loss. In rhinologic diseases, chronic rhinosinusitis, allergic rhinitis, and obstructive sleep apnea are also significantly associated with ER stress. In this review, we provide a comprehensive overview of the relationship between ER stress and otorhinolaryngological diseases, focusing on the current state of knowledge and mechanisms that link ER stress and otorhinolaryngologic diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
International journal of molecular sciences - 21(2020), 11 vom: 09. Juni |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jung, Su Young [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 25.03.2021 Date Revised 25.03.2021 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/ijms21114121 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM311062261 |
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| 520 | |a The endoplasmic reticulum (ER) is an important organelle for normal cellular function and homeostasis in most living things. ER stress, which impairs ER function, occurs when the ER is overwhelmed by newly introduced immature proteins or when calcium in the ER is depleted. A number of diseases are associated with ER stress, including otorhinolaryngological diseases. The relationship between ER stress and otorhinolaryngologic conditions has been the subject of investigation over the last decade. Among otologic diseases associated with ER stress are otitis media and hearing loss. In rhinologic diseases, chronic rhinosinusitis, allergic rhinitis, and obstructive sleep apnea are also significantly associated with ER stress. In this review, we provide a comprehensive overview of the relationship between ER stress and otorhinolaryngological diseases, focusing on the current state of knowledge and mechanisms that link ER stress and otorhinolaryngologic diseases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a allergic rhinitis | |
| 650 | 4 | |a chronic rhinosinusitis | |
| 650 | 4 | |a endoplasmic reticulum stress | |
| 650 | 4 | |a hearing loss | |
| 650 | 4 | |a intermittent hypoxia | |
| 650 | 4 | |a obstructive sleep apnea | |
| 650 | 4 | |a otitis media | |
| 650 | 4 | |a otorhinolaryngologic disease | |
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| 700 | 1 | |a Kim, Sung Su |e verfasserin |4 aut | |
| 700 | 1 | |a Yeo, Seung Geun |e verfasserin |4 aut | |
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