AMTRA : a multicentered experience of a web-based monitoring and tailored toxicity management system for cancer patients
BACKGROUND: Technology-based interventions are increasingly being introduced in routine clinical cancer care. There is a need for reliable systems to monitor treatment-related toxicity in a standardized manner. Such electronic tools bridge the gap in providing quality home-based monitoring.
METHODS: From July 2017 to December 2017, we performed a multicentered, non-randomized prospective cohort analysis with patients who were receiving routine chemotherapy for various solid tumors, using a web-based patient-reported toxicity registration, management, and intervention system called AMTRA (ambulatory Monitoring of cancer Therapy using an interactive Application) linked to the homecare nursing organization Remedus®. Twelve common toxicities plus pain and two biometrics could be registered daily or more frequently as required. These were processed centrally to generate tailored advice for lesser symptoms or a phone call from a dedicated nurse in case of severe or prolonged toxicity. A compliance tool to monitor oral therapies was incorporated in the system.
RESULTS: One hundred sixty-eight patients (92%) were enrolled, with 31,514 registrations analyzed. One hundred eight patients reported severe toxicity (> 1461 registrations), resulting in 102 clinical interventions ranging from self-management advice, supplemental consultations to hospitalizations. Compliance to oral chemotherapy was high using AMTRA with a median of 98.7% (95 confidence interval (CI) [93.5-100.0%]). Seventy-nine percent of patients stated that the availability of AMTRA self-reports was useful in communication with the care provider, while 75% felt more in control while managing their treatment.
CONCLUSIONS: The application of an interactive PRO-system in routine symptom management of cancer patients allowed standardized documentation of toxicities and recorded a high compliance with oral treatment. It allows for rapid interaction for toxicities and cancer-related symptoms experienced at home.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer - 29(2021), 2 vom: 09. Feb., Seite 859-867 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rasschaert, Marika [VerfasserIn] |
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| Links: |
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| Themen: |
Cancer |
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| Anmerkungen: |
Date Completed 22.02.2021 Date Revised 22.02.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00520-020-05550-6 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM31098405X |
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| 100 | 1 | |a Rasschaert, Marika |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a AMTRA |b a multicentered experience of a web-based monitoring and tailored toxicity management system for cancer patients |
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| 500 | |a Date Revised 22.02.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Technology-based interventions are increasingly being introduced in routine clinical cancer care. There is a need for reliable systems to monitor treatment-related toxicity in a standardized manner. Such electronic tools bridge the gap in providing quality home-based monitoring | ||
| 520 | |a METHODS: From July 2017 to December 2017, we performed a multicentered, non-randomized prospective cohort analysis with patients who were receiving routine chemotherapy for various solid tumors, using a web-based patient-reported toxicity registration, management, and intervention system called AMTRA (ambulatory Monitoring of cancer Therapy using an interactive Application) linked to the homecare nursing organization Remedus®. Twelve common toxicities plus pain and two biometrics could be registered daily or more frequently as required. These were processed centrally to generate tailored advice for lesser symptoms or a phone call from a dedicated nurse in case of severe or prolonged toxicity. A compliance tool to monitor oral therapies was incorporated in the system | ||
| 520 | |a RESULTS: One hundred sixty-eight patients (92%) were enrolled, with 31,514 registrations analyzed. One hundred eight patients reported severe toxicity (> 1461 registrations), resulting in 102 clinical interventions ranging from self-management advice, supplemental consultations to hospitalizations. Compliance to oral chemotherapy was high using AMTRA with a median of 98.7% (95 confidence interval (CI) [93.5-100.0%]). Seventy-nine percent of patients stated that the availability of AMTRA self-reports was useful in communication with the care provider, while 75% felt more in control while managing their treatment | ||
| 520 | |a CONCLUSIONS: The application of an interactive PRO-system in routine symptom management of cancer patients allowed standardized documentation of toxicities and recorded a high compliance with oral treatment. It allows for rapid interaction for toxicities and cancer-related symptoms experienced at home | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Patient-reported outcome (PRO) | |
| 650 | 4 | |a Toxicity self-assessment | |
| 650 | 4 | |a Toxicity self-management | |
| 650 | 4 | |a Transmural care | |
| 700 | 1 | |a Vulsteke, Christof |e verfasserin |4 aut | |
| 700 | 1 | |a De Keersmaeker, Sven |e verfasserin |4 aut | |
| 700 | 1 | |a Vandenborne, Kathleen |e verfasserin |4 aut | |
| 700 | 1 | |a Dias, Stefanie |e verfasserin |4 aut | |
| 700 | 1 | |a Verschaeve, Vincent |e verfasserin |4 aut | |
| 700 | 1 | |a Vuylsteke, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Brussel, Ilse Van |e verfasserin |4 aut | |
| 700 | 1 | |a Ravelingien, Jo |e verfasserin |4 aut | |
| 700 | 1 | |a Dam, Peter Van |e verfasserin |4 aut | |
| 700 | 1 | |a Segelov, Eva |e verfasserin |4 aut | |
| 700 | 1 | |a Peeters, Marc |e verfasserin |4 aut | |
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