Long-term outcomes and safety after reirradiation in locally recurrent nasopharyngeal carcinoma in a non-endemic area
PURPOSE: To determine outcomes and toxicities after reirradiation for locally recurrent nasopharyngeal carcinoma (rNPC) and to apply a prognostic index in a non-endemic region.
METHODS: We retrospectively reported progression-free survival (PFS), overall survival (OS), and treatment-related toxicities in patients treated with curative intent for locally rNPC. We applied the prognostic model for OS and grade 5 radiotherapy (RT)-related toxicities published by Li et al. and evaluated its prognostic accuracy by receiver operating characteristic (ROC) curve analysis.
RESULTS: Between 2005 and 2018, 33 patients were treated for rNPC in our institution. Median follow-up was 60 months. The mean time to local recurrence was 75 months. Six (18%) patients had a persistent grade 3 toxicity from a previous RT course. The median re-RT dose was 66 Gy. After re-RT, 13 patients had local failure and 3 patients had metastatic recurrence. Median PFS was 18 months with a 5-year PFS rate of 29%. Median OS was 35 months with a 5-year OS rate of 37%. Grade 3 or higher toxicities rate was 74%. There were 21% grade 5 toxicities. The median time to a grade 5 toxicity was less than 6 months following re-RT. The prognostic nomogram was not predictive for OS or grade 5 toxicities.
CONCLUSION: Reirradiation of rNPC is an effective treatment but is associated with a high rate of life-threatening toxicity. Stratification of patients based on their risk of developing severe toxicity is needed to select patients who will most likely benefit from re-RT.
| Errataetall: |
CommentIn: Strahlenther Onkol. 2021 Aug;197(8):744-745. - PMID 34160633 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:197 |
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| Enthalten in: |
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al - 197(2021), 3 vom: 08. März, Seite 188-197 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Boustani, J [VerfasserIn] |
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| Links: |
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| Themen: |
Head and neck cancer |
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| Anmerkungen: |
Date Completed 04.05.2021 Date Revised 19.08.2021 published: Print-Electronic CommentIn: Strahlenther Onkol. 2021 Aug;197(8):744-745. - PMID 34160633 Citation Status MEDLINE |
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| doi: |
10.1007/s00066-020-01647-3 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310940613 |
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| 245 | 1 | 0 | |a Long-term outcomes and safety after reirradiation in locally recurrent nasopharyngeal carcinoma in a non-endemic area |
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| 500 | |a Date Revised 19.08.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Strahlenther Onkol. 2021 Aug;197(8):744-745. - PMID 34160633 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: To determine outcomes and toxicities after reirradiation for locally recurrent nasopharyngeal carcinoma (rNPC) and to apply a prognostic index in a non-endemic region | ||
| 520 | |a METHODS: We retrospectively reported progression-free survival (PFS), overall survival (OS), and treatment-related toxicities in patients treated with curative intent for locally rNPC. We applied the prognostic model for OS and grade 5 radiotherapy (RT)-related toxicities published by Li et al. and evaluated its prognostic accuracy by receiver operating characteristic (ROC) curve analysis | ||
| 520 | |a RESULTS: Between 2005 and 2018, 33 patients were treated for rNPC in our institution. Median follow-up was 60 months. The mean time to local recurrence was 75 months. Six (18%) patients had a persistent grade 3 toxicity from a previous RT course. The median re-RT dose was 66 Gy. After re-RT, 13 patients had local failure and 3 patients had metastatic recurrence. Median PFS was 18 months with a 5-year PFS rate of 29%. Median OS was 35 months with a 5-year OS rate of 37%. Grade 3 or higher toxicities rate was 74%. There were 21% grade 5 toxicities. The median time to a grade 5 toxicity was less than 6 months following re-RT. The prognostic nomogram was not predictive for OS or grade 5 toxicities | ||
| 520 | |a CONCLUSION: Reirradiation of rNPC is an effective treatment but is associated with a high rate of life-threatening toxicity. Stratification of patients based on their risk of developing severe toxicity is needed to select patients who will most likely benefit from re-RT | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Head and neck cancer | |
| 650 | 4 | |a Prognostic nomogram | |
| 650 | 4 | |a Radiotherapy | |
| 650 | 4 | |a Recurrence | |
| 700 | 1 | |a Ruffier, A |e verfasserin |4 aut | |
| 700 | 1 | |a Moya-Plana, A |e verfasserin |4 aut | |
| 700 | 1 | |a Tao, Y |e verfasserin |4 aut | |
| 700 | 1 | |a Nguyen, F |e verfasserin |4 aut | |
| 700 | 1 | |a Even, C |e verfasserin |4 aut | |
| 700 | 1 | |a Berthold, C |e verfasserin |4 aut | |
| 700 | 1 | |a Casiraghi, O |e verfasserin |4 aut | |
| 700 | 1 | |a Temam, S |e verfasserin |4 aut | |
| 700 | 1 | |a Blanchard, P |e verfasserin |4 aut | |
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