Gut Microbiome Dysbiosis and Depression : a Comprehensive Review
PURPOSE OF REVIEW: The human gut microbiome is involved in a bi-directional communication pathway with the central nervous system (CNS), termed the microbiota-gut-brain axis. The microbiota-gut-brain axis is believed to mediate or modulate various central processes through the vagus nerve. The microbiota-gut-brain axis is involved with the production of microbial metabolites and immune mediators which trigger changes in neurotransmission, neuroinflammation, and behavior. Little is understood about the utilization of microbiome manipulation to treat disease.
RECENT FINDINGS: Though studies exploring the role of the microbiome in various disease processes have shown promise, mechanisms remain unclear and evidence-based treatments for most illnesses have not yet been developed. The animal studies reviewed in the present investigation include an array of basic science studies that clarify mechanisms by which the microbiome may affect mental health. More evidence is needed, particularly as it relates to translating this work to humans. The studies presented in this review demonstrate encouraging results in the treatment of depression. Limitations include small sample sizes and heterogeneous methodology. The exact mechanism by which the gut microbiota causes or alters neuropsychiatric disease states is not fully understood. In this review, we focus on recent studies investigating the relationship between gut microbiome dysbiosis and the pathogenesis of depression.
| Errataetall: |
RetractionIn: Curr Pain Headache Rep. 2023 May;27(5):129. - PMID 36971925 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
Current pain and headache reports - 24(2020), 7 vom: 06. Juni, Seite 36 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Capuco, Alexander [VerfasserIn] |
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| Links: |
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| Themen: |
Anxiety |
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| Anmerkungen: |
Date Completed 06.04.2021 Date Revised 27.03.2023 published: Electronic RetractionIn: Curr Pain Headache Rep. 2023 May;27(5):129. - PMID 36971925 Citation Status MEDLINE |
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| doi: |
10.1007/s11916-020-00871-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310857627 |
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| 500 | |a RetractionIn: Curr Pain Headache Rep. 2023 May;27(5):129. - PMID 36971925 | ||
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| 520 | |a PURPOSE OF REVIEW: The human gut microbiome is involved in a bi-directional communication pathway with the central nervous system (CNS), termed the microbiota-gut-brain axis. The microbiota-gut-brain axis is believed to mediate or modulate various central processes through the vagus nerve. The microbiota-gut-brain axis is involved with the production of microbial metabolites and immune mediators which trigger changes in neurotransmission, neuroinflammation, and behavior. Little is understood about the utilization of microbiome manipulation to treat disease | ||
| 520 | |a RECENT FINDINGS: Though studies exploring the role of the microbiome in various disease processes have shown promise, mechanisms remain unclear and evidence-based treatments for most illnesses have not yet been developed. The animal studies reviewed in the present investigation include an array of basic science studies that clarify mechanisms by which the microbiome may affect mental health. More evidence is needed, particularly as it relates to translating this work to humans. The studies presented in this review demonstrate encouraging results in the treatment of depression. Limitations include small sample sizes and heterogeneous methodology. The exact mechanism by which the gut microbiota causes or alters neuropsychiatric disease states is not fully understood. In this review, we focus on recent studies investigating the relationship between gut microbiome dysbiosis and the pathogenesis of depression | ||
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| 650 | 4 | |a Chronic pain | |
| 650 | 4 | |a Depressive disorder | |
| 650 | 4 | |a Gut microbiota | |
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| 700 | 1 | |a Chun, Rebecca |e verfasserin |4 aut | |
| 700 | 1 | |a Gerald, Brittany |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jason K |e verfasserin |4 aut | |
| 700 | 1 | |a Ngo, Anh L |e verfasserin |4 aut | |
| 700 | 1 | |a Simopoulos, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Kaye, Alan D |e verfasserin |4 aut | |
| 700 | 1 | |a Colontonio, Matthew M |e verfasserin |4 aut | |
| 700 | 1 | |a Parker-Actlis, Tomasina Q |e verfasserin |4 aut | |
| 700 | 1 | |a Fuller, Mitchell C |e verfasserin |4 aut | |
| 700 | 1 | |a Viswanath, Omar |e verfasserin |4 aut | |
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