Inflammatory polyps occur more frequently in inflammatory bowel disease than other colitis patients
BACKGROUND: Colitis is generally considered a risk factor for colon neoplasia. However, not all types of colitis seem to have equal neoplastic transformation potential.
AIM: To determine the prevalence of colorectal polyps in a predominantly African American population with inflammatory bowel disease (IBD) and Non-IBD/Non-Infectious Colitis (NIC).
METHODS: We retrospectively evaluated medical records of 1060 patients previously identified with colitis at Howard University Hospital, based on ICD-10 code. Among these, 485 patients were included in the study: 70 IBD and 415 NIC based on a thorough review of colonoscopy, pathology and clinical reports. Logistic regression analysis was applied to estimate the risk of polyps in patients with IBD compared to those with NIC after adjusting for age and sex. A subgroup analysis within the IBD group was performed.
RESULTS: Of the 485 patients, 415 were NIC and 70 were IBD. Seventy-three percent of the NIC patients and 81% of the IBD patients were African Americans. Forty six percent of IBD and 41% of NIC cases were male. IBD patients were younger than NIC patients (median age of 38 years vs. 50, P < 0.001). The prevalence of all types of polyps was 15.7 and 8.2% in the IBD and NIC groups, respectively (P = 0.045). Among patients with polyps, the prevalence of inflammatory polyps was higher in the IBD group (55%) compared to the NIC group (12%). After adjusting for age, sex and race, odds ratio of inflammatory polyps in IBD patients was 6.0 (P = 0.016). Adenoma prevalence was 4.3% (3/70) in IBD patients and 3.9% (16/415) in the NIC patients (p = 0.75). The anatomic distribution of lesions and colitis shows that polyps occur predominantly in the colitis field regardless of colitis type. More polyps were present in the ulcerative colitis patients when compared to Crohn's disease patients (27% vs. 5%, P < 0.001) within the IBD group.
CONCLUSION: Our study shows that inflammatory polyps are more common in IBD patients when compared to NIC patients. Most polyps were in the same location as the colitis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
BMC gastroenterology - 20(2020), 1 vom: 05. Juni, Seite 170 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ashktorab, Hassan [VerfasserIn] |
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| Links: |
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| Themen: |
Adenoma |
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| Anmerkungen: |
Date Completed 18.03.2021 Date Revised 26.04.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12876-020-01279-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310829720 |
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| 100 | 1 | |a Ashktorab, Hassan |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Inflammatory polyps occur more frequently in inflammatory bowel disease than other colitis patients |
| 264 | 1 | |c 2020 | |
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| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Colitis is generally considered a risk factor for colon neoplasia. However, not all types of colitis seem to have equal neoplastic transformation potential | ||
| 520 | |a AIM: To determine the prevalence of colorectal polyps in a predominantly African American population with inflammatory bowel disease (IBD) and Non-IBD/Non-Infectious Colitis (NIC) | ||
| 520 | |a METHODS: We retrospectively evaluated medical records of 1060 patients previously identified with colitis at Howard University Hospital, based on ICD-10 code. Among these, 485 patients were included in the study: 70 IBD and 415 NIC based on a thorough review of colonoscopy, pathology and clinical reports. Logistic regression analysis was applied to estimate the risk of polyps in patients with IBD compared to those with NIC after adjusting for age and sex. A subgroup analysis within the IBD group was performed | ||
| 520 | |a RESULTS: Of the 485 patients, 415 were NIC and 70 were IBD. Seventy-three percent of the NIC patients and 81% of the IBD patients were African Americans. Forty six percent of IBD and 41% of NIC cases were male. IBD patients were younger than NIC patients (median age of 38 years vs. 50, P < 0.001). The prevalence of all types of polyps was 15.7 and 8.2% in the IBD and NIC groups, respectively (P = 0.045). Among patients with polyps, the prevalence of inflammatory polyps was higher in the IBD group (55%) compared to the NIC group (12%). After adjusting for age, sex and race, odds ratio of inflammatory polyps in IBD patients was 6.0 (P = 0.016). Adenoma prevalence was 4.3% (3/70) in IBD patients and 3.9% (16/415) in the NIC patients (p = 0.75). The anatomic distribution of lesions and colitis shows that polyps occur predominantly in the colitis field regardless of colitis type. More polyps were present in the ulcerative colitis patients when compared to Crohn's disease patients (27% vs. 5%, P < 0.001) within the IBD group | ||
| 520 | |a CONCLUSION: Our study shows that inflammatory polyps are more common in IBD patients when compared to NIC patients. Most polyps were in the same location as the colitis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Adenoma | |
| 650 | 4 | |a African Americans | |
| 650 | 4 | |a Colitis | |
| 650 | 4 | |a IBD | |
| 650 | 4 | |a Inflammatory polyps | |
| 700 | 1 | |a Brim, Hassan |e verfasserin |4 aut | |
| 700 | 1 | |a Hassan, Sally |e verfasserin |4 aut | |
| 700 | 1 | |a Nouraie, Mehdi |e verfasserin |4 aut | |
| 700 | 1 | |a Gebreselassie, Agazi |e verfasserin |4 aut | |
| 700 | 1 | |a Laiyemo, Adeyinka O |e verfasserin |4 aut | |
| 700 | 1 | |a Kibreab, Angesom |e verfasserin |4 aut | |
| 700 | 1 | |a Aduli, Farshad |e verfasserin |4 aut | |
| 700 | 1 | |a Latella, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Brant, Steven R |e verfasserin |4 aut | |
| 700 | 1 | |a Sherif, Zaki |e verfasserin |4 aut | |
| 700 | 1 | |a Habtezion, Aida |e verfasserin |4 aut | |
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