Mycobacterial Virulence Factors : Surface-Exposed Lipids and Secreted Proteins
The clinically important Mycobacterium tuberculosis (M. tb) and related mycobacterial pathogens use various virulence mechanisms to survive and cause disease in their hosts. Several well-established virulence factors include the surface-exposed lipids in the mycobacterial outer membrane, as well as the Esx family proteins and the Pro-Glu (PE)/ Pro-Pro-Glu (PPE) family proteins secreted by type VII secretion systems (T7SS). Five ESX T7SS exist in M. tb and three-EsxA secretion system-1 (ESX-1), ESX-3, and ESX-5-have been implicated in virulence, yet only the structures of ESX-3 and ESX-5 have been solved to date. Here, we summarize the current research on three outer membrane lipids-phthiocerol dimycocerosates, phenolic glycolipids, and sulfolipids-as well as the secretion machinery and substrates of three mycobacterial T7SS-ESX-1, ESX-3, and ESX-5. We propose a structural model of the M. tb ESX-1 system based on the latest structural findings of the ESX-3 and ESX-5 secretion apparatuses to gain insight into the transport mechanism of ESX-associated virulence factors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
International journal of molecular sciences - 21(2020), 11 vom: 02. Juni |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
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| Links: |
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| Anmerkungen: |
Date Completed 30.03.2021 Date Revised 30.03.2021 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/ijms21113985 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310778239 |
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| 100 | 1 | |a Ly, Angel |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Mycobacterial Virulence Factors |b Surface-Exposed Lipids and Secreted Proteins |
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| 500 | |a Date Completed 30.03.2021 | ||
| 500 | |a Date Revised 30.03.2021 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The clinically important Mycobacterium tuberculosis (M. tb) and related mycobacterial pathogens use various virulence mechanisms to survive and cause disease in their hosts. Several well-established virulence factors include the surface-exposed lipids in the mycobacterial outer membrane, as well as the Esx family proteins and the Pro-Glu (PE)/ Pro-Pro-Glu (PPE) family proteins secreted by type VII secretion systems (T7SS). Five ESX T7SS exist in M. tb and three-EsxA secretion system-1 (ESX-1), ESX-3, and ESX-5-have been implicated in virulence, yet only the structures of ESX-3 and ESX-5 have been solved to date. Here, we summarize the current research on three outer membrane lipids-phthiocerol dimycocerosates, phenolic glycolipids, and sulfolipids-as well as the secretion machinery and substrates of three mycobacterial T7SS-ESX-1, ESX-3, and ESX-5. We propose a structural model of the M. tb ESX-1 system based on the latest structural findings of the ESX-3 and ESX-5 secretion apparatuses to gain insight into the transport mechanism of ESX-associated virulence factors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Mycobacterium tuberculosis | |
| 650 | 4 | |a mycobacteria | |
| 650 | 4 | |a pathogenesis | |
| 650 | 4 | |a type VII secretion systems | |
| 650 | 4 | |a virulence factors | |
| 650 | 7 | |a Antigens, Bacterial |2 NLM | |
| 650 | 7 | |a Bacterial Proteins |2 NLM | |
| 650 | 7 | |a ESAT-6 protein, Mycobacterium tuberculosis |2 NLM | |
| 650 | 7 | |a ESX-5 protein, Mycobacterium tuberculosis |2 NLM | |
| 650 | 7 | |a Glycolipids |2 NLM | |
| 650 | 7 | |a Lipids |2 NLM | |
| 650 | 7 | |a Virulence Factors |2 NLM | |
| 650 | 7 | |a sulfolipids |2 NLM | |
| 650 | 7 | |a Phenol |2 NLM | |
| 650 | 7 | |a 339NCG44TV |2 NLM | |
| 650 | 7 | |a phthiocerol dimycocerosate |2 NLM | |
| 650 | 7 | |a 63642-22-8 |2 NLM | |
| 700 | 1 | |a Liu, Jun |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:21 |g year:2020 |g number:11 |g day:02 |g month:06 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3390/ijms21113985 |3 Volltext |
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