Evidence for mutations in SARS-CoV-2 Italian isolates potentially affecting virus transmission
© 2020 Wiley Periodicals LLC..
Italy is the first western country suffering heavy severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and disease impact after coronavirus disease-2019 pandemia started in China. Even though the presence of mutations on spike glycoprotein and nucleocapsid in Italian isolates has been reported, the potential impact of these mutations on viral transmission has not been evaluated. We have compared SARS-CoV-2 genome sequences from Italian patients with virus sequences from Chinese patients. We focussed upon three nonsynonymous mutations of genes coding for S(one) and N (two) viral proteins present in Italian isolates and absent in Chinese ones, using various bioinformatics tools. Amino acid analysis and changes in three-dimensional protein structure suggests the mutations reduce protein stability and, particularly for S1 mutation, the enhanced torsional ability of the molecule could favor virus binding to cell receptor(s). This theoretical interpretation awaits experimental and clinical confirmation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:92 |
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| Enthalten in: |
Journal of medical virology - 92(2020), 10 vom: 03. Okt., Seite 2232-2237 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Benvenuto, Domenico [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 29.12.2020 Date Revised 16.07.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/jmv.26104 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM31071852X |
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| 520 | |a © 2020 Wiley Periodicals LLC. | ||
| 520 | |a Italy is the first western country suffering heavy severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and disease impact after coronavirus disease-2019 pandemia started in China. Even though the presence of mutations on spike glycoprotein and nucleocapsid in Italian isolates has been reported, the potential impact of these mutations on viral transmission has not been evaluated. We have compared SARS-CoV-2 genome sequences from Italian patients with virus sequences from Chinese patients. We focussed upon three nonsynonymous mutations of genes coding for S(one) and N (two) viral proteins present in Italian isolates and absent in Chinese ones, using various bioinformatics tools. Amino acid analysis and changes in three-dimensional protein structure suggests the mutations reduce protein stability and, particularly for S1 mutation, the enhanced torsional ability of the molecule could favor virus binding to cell receptor(s). This theoretical interpretation awaits experimental and clinical confirmation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a SARS coronavirus | |
| 650 | 4 | |a bioinformatics | |
| 650 | 4 | |a molecular evolution | |
| 650 | 4 | |a mutation | |
| 650 | 7 | |a Coronavirus Nucleocapsid Proteins |2 NLM | |
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| 650 | 7 | |a spike protein, SARS-CoV-2 |2 NLM | |
| 700 | 1 | |a Demir, Ayse Banu |e verfasserin |4 aut | |
| 700 | 1 | |a Giovanetti, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Bianchi, Martina |e verfasserin |4 aut | |
| 700 | 1 | |a Angeletti, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a Pascarella, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Cauda, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Ciccozzi, Massimo |e verfasserin |4 aut | |
| 700 | 1 | |a Cassone, Antonio |e verfasserin |4 aut | |
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