Oxytocin reverses Aβ-induced impairment of hippocampal synaptic plasticity in mice
Copyright © 2020 Elsevier Inc. All rights reserved..
AIM: Oxytocin, a peptide hormone synthesized in the hypothalamic paraventricular nucleus, has been reported to participate in the regulation of learning and memory performance. However, no report has demonstrated the effect of oxytocin on the amyloid-beta (Aβ)-induced impairment of synaptic plasticity. In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice.
METHODS: To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin.
RESULTS: We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the treatment with the ERK inhibitor U0126 and selective Ca2+-permeable AMPA receptor antagonist NASPM completely antagonized the effects of oxytocin.
CONCLUSION: This is the first report to demonstrate that oxytocin could reverse the effects of Aβ on hippocampal LTP in mice. We propose that ERK phosphorylation and Ca2+-permeable AMPA receptors are involved in this effect of oxytocin.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:528 |
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| Enthalten in: |
Biochemical and biophysical research communications - 528(2020), 1 vom: 12. Juli, Seite 174-178 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Takahashi, Junpei [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 13.01.2021 Date Revised 13.01.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bbrc.2020.04.046 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310627885 |
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| 100 | 1 | |a Takahashi, Junpei |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Oxytocin reverses Aβ-induced impairment of hippocampal synaptic plasticity in mice |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 13.01.2021 | ||
| 500 | |a Date Revised 13.01.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier Inc. All rights reserved. | ||
| 520 | |a AIM: Oxytocin, a peptide hormone synthesized in the hypothalamic paraventricular nucleus, has been reported to participate in the regulation of learning and memory performance. However, no report has demonstrated the effect of oxytocin on the amyloid-beta (Aβ)-induced impairment of synaptic plasticity. In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice | ||
| 520 | |a METHODS: To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin | ||
| 520 | |a RESULTS: We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the treatment with the ERK inhibitor U0126 and selective Ca2+-permeable AMPA receptor antagonist NASPM completely antagonized the effects of oxytocin | ||
| 520 | |a CONCLUSION: This is the first report to demonstrate that oxytocin could reverse the effects of Aβ on hippocampal LTP in mice. We propose that ERK phosphorylation and Ca2+-permeable AMPA receptors are involved in this effect of oxytocin | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Amyloid beta peptide | |
| 650 | 4 | |a Hippocampus | |
| 650 | 4 | |a Long-term potentiation | |
| 650 | 4 | |a Oxytocin | |
| 650 | 4 | |a Synaptic plasticity | |
| 650 | 7 | |a Amyloid beta-Peptides |2 NLM | |
| 650 | 7 | |a Receptors, AMPA |2 NLM | |
| 650 | 7 | |a Oxytocin |2 NLM | |
| 650 | 7 | |a 50-56-6 |2 NLM | |
| 650 | 7 | |a Extracellular Signal-Regulated MAP Kinases |2 NLM | |
| 650 | 7 | |a EC 2.7.11.24 |2 NLM | |
| 650 | 7 | |a Calcium |2 NLM | |
| 650 | 7 | |a SY7Q814VUP |2 NLM | |
| 700 | 1 | |a Yamada, Daisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Ueta, Yudai |e verfasserin |4 aut | |
| 700 | 1 | |a Iwai, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Koga, Eri |e verfasserin |4 aut | |
| 700 | 1 | |a Tanabe, Mitsuo |e verfasserin |4 aut | |
| 700 | 1 | |a Oka, Jun-Ichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Saitoh, Akiyoshi |e verfasserin |4 aut | |
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