Prevalence and risk factors for pulmonary embolism in patients with suspected acute exacerbation of COPD : a multi-center study
Copyright © 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved..
INTRODUCTION: Pulmonary embolism (PE) prevalence in acute exacerbations of COPD is highly variable.
METHODS: To investigate the prevalence and risk factors of PE in patients hospitalized in Departments of Internal Medicine because of AECOPD and suspected PE we conducted a retrospective multicenter study in patients with an AECOPD undergoing chest angio-computed tomography (angio-CT) because of clinical suspect of PE.
RESULTS: 1043 patients (mean age 75.8 years ± 9.7 years, 34.5 % women) were included; 132 patients had PE (mean prevalence 12.66%, 95% confidence interval 10.73, 14.77%).) confirmed by angio-CT and 54 patients died during hospitalization (5.18 %). At multivariate analysis, age, female gender, clinical signs and symptoms suggestive of deep vein thrombosis, hypertension, PaCO2 ≤ 40 mmHg, and normal chest-x-ray were significantly associated with a higher PE prevalence. Prevalence of PE in patients with 0, 1, 2, 3 or ≥4 risk factors progressively increase from 1.76 to 30.43%. Mean length of hospitalization (LOH) (15.7 vs 14.2 days, p 0.07) and in-hospital mortality (6.1% vs 5.1%, P=0.62) were slightly but not significantly higher in in patients with PE (6.1% vs 5.1%, P=0.62).
CONCLUSIONS: PE prevalence is not negligible in this setting. A number of risk factors may help clinicians in identification of patients at increased risk of PE.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:80 |
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| Enthalten in: |
European journal of internal medicine - 80(2020) vom: 01. Okt., Seite 54-59 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dentali, Francesco [VerfasserIn] |
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| Anmerkungen: |
Date Completed 15.02.2021 Date Revised 15.02.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ejim.2020.05.006 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310545021 |
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| 100 | 1 | |a Dentali, Francesco |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prevalence and risk factors for pulmonary embolism in patients with suspected acute exacerbation of COPD |b a multi-center study |
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| 500 | |a Date Revised 15.02.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a INTRODUCTION: Pulmonary embolism (PE) prevalence in acute exacerbations of COPD is highly variable | ||
| 520 | |a METHODS: To investigate the prevalence and risk factors of PE in patients hospitalized in Departments of Internal Medicine because of AECOPD and suspected PE we conducted a retrospective multicenter study in patients with an AECOPD undergoing chest angio-computed tomography (angio-CT) because of clinical suspect of PE | ||
| 520 | |a RESULTS: 1043 patients (mean age 75.8 years ± 9.7 years, 34.5 % women) were included; 132 patients had PE (mean prevalence 12.66%, 95% confidence interval 10.73, 14.77%).) confirmed by angio-CT and 54 patients died during hospitalization (5.18 %). At multivariate analysis, age, female gender, clinical signs and symptoms suggestive of deep vein thrombosis, hypertension, PaCO2 ≤ 40 mmHg, and normal chest-x-ray were significantly associated with a higher PE prevalence. Prevalence of PE in patients with 0, 1, 2, 3 or ≥4 risk factors progressively increase from 1.76 to 30.43%. Mean length of hospitalization (LOH) (15.7 vs 14.2 days, p 0.07) and in-hospital mortality (6.1% vs 5.1%, P=0.62) were slightly but not significantly higher in in patients with PE (6.1% vs 5.1%, P=0.62) | ||
| 520 | |a CONCLUSIONS: PE prevalence is not negligible in this setting. A number of risk factors may help clinicians in identification of patients at increased risk of PE | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 700 | 1 | |a Pomero, Fulvio |e verfasserin |4 aut | |
| 700 | 1 | |a Micco, Pierpaolo Di |e verfasserin |4 aut | |
| 700 | 1 | |a La Regina, Micaela |e verfasserin |4 aut | |
| 700 | 1 | |a Landini, Federica |e verfasserin |4 aut | |
| 700 | 1 | |a Mumoli, Nicola |e verfasserin |4 aut | |
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| 700 | 1 | |a Giorgi-Pierfranceschi, Matteo |e verfasserin |4 aut | |
| 700 | 1 | |a Re, Roberta |e verfasserin |4 aut | |
| 700 | 1 | |a Vitale, Josè |e verfasserin |4 aut | |
| 700 | 1 | |a Fabbri, Leonardo M |e verfasserin |4 aut | |
| 700 | 1 | |a Fontanella, Andrea |e verfasserin |4 aut | |
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