Applicability of the CURB-65 pneumonia severity score for outpatient treatment of COVID-19
Copyright © 2020. Published by Elsevier Ltd..
OBJECTIVES: The CURB-65 is a severity score to predict mortality secondary to community acquired pneumonia and is widely used to identify patients who can be managed as outpatients. However, whether CURB-65 can be applicable to COVID-19 patients for the decision of outpatient treatment is still unknown.
METHODS: We conducted a retrospective single-centre study assessing the performance of the CURB-65 to predict the risk of poor outcome, defined as the need for mechanical ventilation and/or death, among patients hospitalized for COVID-19. The association between the CURB-65 and the outcome was assessed by a univariable Cox proportional hazard regression model.
RESULTS: A total of 279 patients were hospitalized between March 15th and April 14th, 2020. According to the CURB-65, 171 (61.3%) patients were considered at low risk (CURB-65 01), 66 (23.7%) at intermediate risk (CURB-65=2), and 42 (15.1%) had high risk of 30-day mortality (CURB-65 35). During the study period, 88 (31.5%) patients had a poor outcome. The CURB-65 was strongly associated with a poor outcome (Pfor linear trend <0.001). However, among patients with a CURB-65 of 01, thus considered at low risk, 36/171 (21.1%) had a poor outcome.
CONCLUSIONS: Our study suggests that the applicability of CURB-65 to guide the decision of inpatient or outpatient care is scarce, as it does not safely identify patients who could be managed as outpatients.
| Errataetall: |
CommentOn: J Infect. 2020 Aug;81(2):e59-e61. - PMID 32353384 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:81 |
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| Enthalten in: |
The Journal of infection - 81(2020), 3 vom: 01. Sept., Seite e96-e98 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nguyen, Yann [VerfasserIn] |
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| Anmerkungen: |
Date Completed 21.08.2020 Date Revised 10.01.2021 published: Print-Electronic CommentOn: J Infect. 2020 Aug;81(2):e59-e61. - PMID 32353384 Citation Status MEDLINE |
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| doi: |
10.1016/j.jinf.2020.05.049 |
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| PPN (Katalog-ID): |
NLM310544882 |
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| 500 | |a Date Revised 10.01.2021 | ||
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| 500 | |a CommentOn: J Infect. 2020 Aug;81(2):e59-e61. - PMID 32353384 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020. Published by Elsevier Ltd. | ||
| 520 | |a OBJECTIVES: The CURB-65 is a severity score to predict mortality secondary to community acquired pneumonia and is widely used to identify patients who can be managed as outpatients. However, whether CURB-65 can be applicable to COVID-19 patients for the decision of outpatient treatment is still unknown | ||
| 520 | |a METHODS: We conducted a retrospective single-centre study assessing the performance of the CURB-65 to predict the risk of poor outcome, defined as the need for mechanical ventilation and/or death, among patients hospitalized for COVID-19. The association between the CURB-65 and the outcome was assessed by a univariable Cox proportional hazard regression model | ||
| 520 | |a RESULTS: A total of 279 patients were hospitalized between March 15th and April 14th, 2020. According to the CURB-65, 171 (61.3%) patients were considered at low risk (CURB-65 01), 66 (23.7%) at intermediate risk (CURB-65=2), and 42 (15.1%) had high risk of 30-day mortality (CURB-65 35). During the study period, 88 (31.5%) patients had a poor outcome. The CURB-65 was strongly associated with a poor outcome (Pfor linear trend <0.001). However, among patients with a CURB-65 of 01, thus considered at low risk, 36/171 (21.1%) had a poor outcome | ||
| 520 | |a CONCLUSIONS: Our study suggests that the applicability of CURB-65 to guide the decision of inpatient or outpatient care is scarce, as it does not safely identify patients who could be managed as outpatients | ||
| 650 | 4 | |a Letter | |
| 650 | 4 | |a Comment | |
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| 650 | 4 | |a CURB-65 | |
| 650 | 4 | |a Outpatient care | |
| 650 | 4 | |a Risk factor | |
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| 700 | 1 | |a Galy, Adrien |e verfasserin |4 aut | |
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