Health risk assessment of aflatoxin M1 in infant formula milk in IR Iran
Copyright © 2020 Elsevier Ltd. All rights reserved..
In this study, two accurate, precise, selective and sensitive methods were developed for determining aflatoxin M1 (AFM1) in infant formula milk using immunoaffinity column clean-up followed by high performance liquid chromatography (HPLC) with fluorescence detection. The validated methods were used for determination of AFM1 in 29 samples of 6 different infant formula milk brands and the risk of AFM1 in infants aged zero to 6 months old was assessed using cancer risk, Margin of Exposure (MOE) and Hazard Index (HI). Only one sample (3.4%) was contaminated with AFM1. Although the results showed that MOE values for the mean and median exposure to AFM1 was <10,000 in infants, the additional cancer risk due to mean and median exposure to AFM1 in infant <6 months were 0.00010 and 0.00012 additional cases per year per 105 individuals, respectively, which indicates no health concern. In addition, HI values for the mean and median exposure to AFM1 for infants were quite below one which indicates no health concern. To the best of our knowledge, this is the first report on risk assessment of AFM1 in infant formula milk consumed by Iranian infants <6 months old, presenting a low risk for the evaluated groups.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:142 |
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| Enthalten in: |
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 142(2020) vom: 01. Aug., Seite 111455 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hooshfar, Shirin [VerfasserIn] |
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| Links: |
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| Themen: |
6795-23-9 |
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| Anmerkungen: |
Date Completed 29.03.2021 Date Revised 29.03.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.fct.2020.111455 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310544726 |
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| 520 | |a Copyright © 2020 Elsevier Ltd. All rights reserved. | ||
| 520 | |a In this study, two accurate, precise, selective and sensitive methods were developed for determining aflatoxin M1 (AFM1) in infant formula milk using immunoaffinity column clean-up followed by high performance liquid chromatography (HPLC) with fluorescence detection. The validated methods were used for determination of AFM1 in 29 samples of 6 different infant formula milk brands and the risk of AFM1 in infants aged zero to 6 months old was assessed using cancer risk, Margin of Exposure (MOE) and Hazard Index (HI). Only one sample (3.4%) was contaminated with AFM1. Although the results showed that MOE values for the mean and median exposure to AFM1 was <10,000 in infants, the additional cancer risk due to mean and median exposure to AFM1 in infant <6 months were 0.00010 and 0.00012 additional cases per year per 105 individuals, respectively, which indicates no health concern. In addition, HI values for the mean and median exposure to AFM1 for infants were quite below one which indicates no health concern. To the best of our knowledge, this is the first report on risk assessment of AFM1 in infant formula milk consumed by Iranian infants <6 months old, presenting a low risk for the evaluated groups | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a HPLC | |
| 650 | 4 | |a IR Iran | |
| 650 | 4 | |a Infant formula milks | |
| 650 | 4 | |a Risk assessment | |
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| 700 | 1 | |a Yazdanpanah, Hassan |e verfasserin |4 aut | |
| 700 | 1 | |a Eslamizad, Samira |e verfasserin |4 aut | |
| 700 | 1 | |a Kobarfard, Farzad |e verfasserin |4 aut | |
| 700 | 1 | |a Nazari, Firouzeh |e verfasserin |4 aut | |
| 700 | 1 | |a Kokaraki, Venetia |e verfasserin |4 aut | |
| 700 | 1 | |a Kokkinakis, Manolis |e verfasserin |4 aut | |
| 700 | 1 | |a Goumenou, Marina |e verfasserin |4 aut | |
| 700 | 1 | |a Tsitsimpikou, Christina |e verfasserin |4 aut | |
| 700 | 1 | |a Tsatsakis, Aristides |e verfasserin |4 aut | |
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