Body Mass Index Predicts Decline in Executive Function in Bipolar Disorder : Preliminary Data of a 12-Month Follow-up Study
© 2020 S. Karger AG, Basel..
INTRODUCTION: Obesity and associated risk factors have been linked to cognitive decline before.
OBJECTIVES: In the present study, we evaluated potential cumulative negative effects of overweight and obesity on cognitive performance in euthymic patients with bipolar disorder (BD) in a longitudinal design.
METHODS: Neurocognitive measures (California Verbal Learning Test, Trail Making Test [TMT] A/B, Digit-Symbol-Test, Digit-Span, d2 Test), anthropometrics (e.g., body mass index [BMI]), and clinical ratings (Hamilton Depression Scale, Young Mania Rating Scale) were collected over a 12-month observation period. Follow-up data of 38 patients with BD (mean age 40 years; 15 males, 23 females) were available.
RESULTS: High baseline BMI predicted a decrease in the patient's performance in the Digit-Span backwards task measuring working memory performance. In contrast, cognitive performance was not predicted by increases in BMI at follow-up. Normal weight bipolar patients (n = 19) improved their performance on the TMT B, measuring cognitive flexibility and executive functioning, within 1 year, while overweight bipolar patients (n = 19) showed no change in this task.
CONCLUSIONS: The results suggest that overweight can predict cognitive performance changes over 12 months.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:80 |
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| Enthalten in: |
Neuropsychobiology - 80(2021), 1 vom: 06., Seite 1-11 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dalkner, Nina [VerfasserIn] |
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| Links: |
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| Themen: |
Cognitive function |
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| Anmerkungen: |
Date Completed 18.10.2021 Date Revised 18.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1159/000505784 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM310365236 |
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| 100 | 1 | |a Dalkner, Nina |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Body Mass Index Predicts Decline in Executive Function in Bipolar Disorder |b Preliminary Data of a 12-Month Follow-up Study |
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| 500 | |a Date Revised 18.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 S. Karger AG, Basel. | ||
| 520 | |a INTRODUCTION: Obesity and associated risk factors have been linked to cognitive decline before | ||
| 520 | |a OBJECTIVES: In the present study, we evaluated potential cumulative negative effects of overweight and obesity on cognitive performance in euthymic patients with bipolar disorder (BD) in a longitudinal design | ||
| 520 | |a METHODS: Neurocognitive measures (California Verbal Learning Test, Trail Making Test [TMT] A/B, Digit-Symbol-Test, Digit-Span, d2 Test), anthropometrics (e.g., body mass index [BMI]), and clinical ratings (Hamilton Depression Scale, Young Mania Rating Scale) were collected over a 12-month observation period. Follow-up data of 38 patients with BD (mean age 40 years; 15 males, 23 females) were available | ||
| 520 | |a RESULTS: High baseline BMI predicted a decrease in the patient's performance in the Digit-Span backwards task measuring working memory performance. In contrast, cognitive performance was not predicted by increases in BMI at follow-up. Normal weight bipolar patients (n = 19) improved their performance on the TMT B, measuring cognitive flexibility and executive functioning, within 1 year, while overweight bipolar patients (n = 19) showed no change in this task | ||
| 520 | |a CONCLUSIONS: The results suggest that overweight can predict cognitive performance changes over 12 months | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Cognitive function | |
| 650 | 4 | |a Longitudinal | |
| 650 | 4 | |a Overweight | |
| 650 | 4 | |a Psychiatry | |
| 650 | 4 | |a Psychopathology | |
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