Anterior EEG slowing in dementia with Lewy bodies : a multicenter European cohort study
Copyright © 2020 Elsevier Inc. All rights reserved..
Electroencephalography (EEG) slowing with prealpha dominant frequency (DF) in posterior derivations is a biomarker for dementia with Lewy bodies (DLB) diagnosis, in contrast with Alzheimer's disease (AD). However, an intrasubject re-evaluation of the original data, which contributed to the identification of EEG DLB biomarker, showed that DF was slower in anterior than posterior derivations. We suppose this anterior-posterior gradient of DF slowing could arise in DLB from a thalamocortical dysrhythmia, differently involving the anterior and posterior cortical areas, and correlating with cognitive impairment (Mini-Mental State Examination). EEG was recorded in 144 DLB, 116 AD, and 65 controls from 7 Centers of the European DLB Consortium. Spectra were divided into delta, theta, prealpha, alpha frequency bands. In DLB, mean DF was prealpha both anteriorly and posteriorly, but lower anteriorly (p < 0.001). In 14% of DLB, DF was prealpha anteriorly, whereas alpha posteriorly. In AD and controls, DF was constantly alpha. EEG slowing in DLB correlated with cognitive impairment. Thalamocortical dysrhythmia gives rise to prealpha rhythm with an anterior-posterior gradient and correlates with impaired cognition.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:93 |
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| Enthalten in: |
Neurobiology of aging - 93(2020) vom: 01. Sept., Seite 55-60 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Franciotti, Raffaella [VerfasserIn] |
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| Links: |
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| Themen: |
Dementia with Lewy bodies |
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| Anmerkungen: |
Date Completed 15.01.2021 Date Revised 15.01.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.neurobiolaging.2020.04.023 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310326133 |
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| 520 | |a Electroencephalography (EEG) slowing with prealpha dominant frequency (DF) in posterior derivations is a biomarker for dementia with Lewy bodies (DLB) diagnosis, in contrast with Alzheimer's disease (AD). However, an intrasubject re-evaluation of the original data, which contributed to the identification of EEG DLB biomarker, showed that DF was slower in anterior than posterior derivations. We suppose this anterior-posterior gradient of DF slowing could arise in DLB from a thalamocortical dysrhythmia, differently involving the anterior and posterior cortical areas, and correlating with cognitive impairment (Mini-Mental State Examination). EEG was recorded in 144 DLB, 116 AD, and 65 controls from 7 Centers of the European DLB Consortium. Spectra were divided into delta, theta, prealpha, alpha frequency bands. In DLB, mean DF was prealpha both anteriorly and posteriorly, but lower anteriorly (p < 0.001). In 14% of DLB, DF was prealpha anteriorly, whereas alpha posteriorly. In AD and controls, DF was constantly alpha. EEG slowing in DLB correlated with cognitive impairment. Thalamocortical dysrhythmia gives rise to prealpha rhythm with an anterior-posterior gradient and correlates with impaired cognition | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Dementia with Lewy bodies | |
| 650 | 4 | |a EEG rhythms | |
| 650 | 4 | |a Thalamocortical dysfunctions | |
| 700 | 1 | |a Pilotto, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Moretti, Davide V |e verfasserin |4 aut | |
| 700 | 1 | |a Falasca, Nicola Walter |e verfasserin |4 aut | |
| 700 | 1 | |a Arnaldi, Dario |e verfasserin |4 aut | |
| 700 | 1 | |a Taylor, John-Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Nobili, Flavio |e verfasserin |4 aut | |
| 700 | 1 | |a Kramberger, Milica |e verfasserin |4 aut | |
| 700 | 1 | |a Ptacek, Sara Garcia |e verfasserin |4 aut | |
| 700 | 1 | |a Padovani, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Aarlsand, Dag |e verfasserin |4 aut | |
| 700 | 1 | |a Onofrj, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Bonanni, Laura |e verfasserin |4 aut | |
| 700 | 0 | |a E-DLB consortium |e verfasserin |4 aut | |
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