Ligation-assisted endoscopic mucosal resection for esophageal granular cell tumors is safe and effective
© The Author(s) 2020. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
Given their malignant potential, resection of esophageal granular cell tumors (GCTs) is often undertaken, yet the optimal technique is unknown. We present a large series of dedicated endoscopic resection using band ligation (EMR-B) of esophageal GCTs. Patients diagnosed with esophageal GCTs between 2002 and 2019 were identified using a prospectively collected pathology database. Endoscopic reports were reviewed, and patients who underwent dedicated EMR-B of esophageal GCTs were included. Medical records were queried for demographics, findings, adverse events, and follow-up. We identified 21 patients who underwent dedicated EMR-B for previously identified esophageal GCT. Median age was 39 years; 16 (76%) were female. Eight (38%) had preceding signs or symptoms, potentially attributable to the GCT. Upon endoscopic evaluation, 12 (57%) were found in the distal esophagus. Endoscopic ultrasound was used in 15 cases (71%). Median lesion size was 7 mm, interquartile range 4 mm-8 mm. The largest lesion was 12 mm. A total of 20 (95%) had en bloc resection confirmed with pathologic examination. The only patient with tumor extending to the resection margin underwent surveillance endoscopy that showed no residual tumor. No patients experienced bleeding, perforation, or stricturing in our series. No patients have had known recurrence of their esophageal GCT. EMR-B of esophageal GCT achieves complete histopathologic resection with minimal adverse events. EMR-B is safe and effective and seems prudent compared with observation for what could be an aggressive and malignant tumor. EMR-B should be considered first-line therapy when resecting esophageal GCT up to 12 mm in diameter.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
|---|---|
| Enthalten in: |
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus - 33(2020), 8 vom: 03. Aug. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kumar, Shria [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Endoscopic mucosal resection |
|---|
| Anmerkungen: |
Date Completed 28.07.2021 Date Revised 28.07.2021 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1093/dote/doaa027 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM310310652 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM310310652 | ||
| 003 | DE-627 | ||
| 005 | 20231225135823.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/dote/doaa027 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1034.xml |
| 035 | |a (DE-627)NLM310310652 | ||
| 035 | |a (NLM)32448896 | ||
| 035 | |a (PII)doaa027 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kumar, Shria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Ligation-assisted endoscopic mucosal resection for esophageal granular cell tumors is safe and effective |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 28.07.2021 | ||
| 500 | |a Date Revised 28.07.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2020. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a Given their malignant potential, resection of esophageal granular cell tumors (GCTs) is often undertaken, yet the optimal technique is unknown. We present a large series of dedicated endoscopic resection using band ligation (EMR-B) of esophageal GCTs. Patients diagnosed with esophageal GCTs between 2002 and 2019 were identified using a prospectively collected pathology database. Endoscopic reports were reviewed, and patients who underwent dedicated EMR-B of esophageal GCTs were included. Medical records were queried for demographics, findings, adverse events, and follow-up. We identified 21 patients who underwent dedicated EMR-B for previously identified esophageal GCT. Median age was 39 years; 16 (76%) were female. Eight (38%) had preceding signs or symptoms, potentially attributable to the GCT. Upon endoscopic evaluation, 12 (57%) were found in the distal esophagus. Endoscopic ultrasound was used in 15 cases (71%). Median lesion size was 7 mm, interquartile range 4 mm-8 mm. The largest lesion was 12 mm. A total of 20 (95%) had en bloc resection confirmed with pathologic examination. The only patient with tumor extending to the resection margin underwent surveillance endoscopy that showed no residual tumor. No patients experienced bleeding, perforation, or stricturing in our series. No patients have had known recurrence of their esophageal GCT. EMR-B of esophageal GCT achieves complete histopathologic resection with minimal adverse events. EMR-B is safe and effective and seems prudent compared with observation for what could be an aggressive and malignant tumor. EMR-B should be considered first-line therapy when resecting esophageal GCT up to 12 mm in diameter | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a endoscopic mucosal resection | |
| 650 | 4 | |a flexible endoscopy | |
| 650 | 4 | |a granular cell tumor | |
| 700 | 1 | |a Chandrasekhara, Vinay |e verfasserin |4 aut | |
| 700 | 1 | |a Kochman, Michael L |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmad, Nuzhat |e verfasserin |4 aut | |
| 700 | 1 | |a Attalla, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Ho, Immanuel K |e verfasserin |4 aut | |
| 700 | 1 | |a Jaffe, David L |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Peter J |e verfasserin |4 aut | |
| 700 | 1 | |a Panganamamula, Kashyap V |e verfasserin |4 aut | |
| 700 | 1 | |a Saumoy, Monica |e verfasserin |4 aut | |
| 700 | 1 | |a Fortuna, Danielle |e verfasserin |4 aut | |
| 700 | 1 | |a Ginsberg, Gregory G |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus |d 1996 |g 33(2020), 8 vom: 03. Aug. |w (DE-627)NLM087786362 |x 1442-2050 |7 nnns |
| 773 | 1 | 8 | |g volume:33 |g year:2020 |g number:8 |g day:03 |g month:08 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/dote/doaa027 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 33 |j 2020 |e 8 |b 03 |c 08 | ||