Clinical and coagulation characteristics in 7 patients with critical COVID-2019 pneumonia and acro-ischemia
Objective: To investigate the clinical and coagulation characteristics in patients with critical Coronavirus disease 2019 (COVID-19) and acro-ischemia. Methods: The retrospective study included 7 critical COVID-19 patients with acro-ischemia in an intensive care unit (ICU) in Wuhan, from Feb 4 to Feb 15, 2020. The clinical and laboratory data before and during the ICU stay were analyzed. Results: The median age of 7 patients was 59 years and 4 of them were men. Three patients were associated with underlying comorbidities. Fever, cough, dyspnea and diarrhea were common clinical symptoms. All patients had acro-ischemia presentations including finger/toe cyanosis, skin bulla and dry gangrene. D-dimer, fibrinogen and fibrinogen degradation product (FDP) were significantly elevated in most patients. Prothrombin time was prolonged in 4 patients. D-dimer and FDP levels progressively elevated consistent with COVID-2019 exacerbation. Four patients were diagnosed with disseminated intravascular coagulation (DIC) . Low molecular weight heparin (LMWH) was administrated in 6 patients, which reduced D-dimer and FDP rather than improved clinical symptoms. Five patients died finally and the median time from acro-ischemia to death was 12 days. Conclusions: Coagulation parameters should be monitored closely in critical COVID-2019 patients. The timing and protocol of anticoagulation therapy are still under investigation based on more clinical data.
| Errataetall: |
CommentIn: J Med Virol. 2021 Jan;93(1):76-77. - PMID 32497287 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
|---|---|
| Enthalten in: |
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 41(2020), 4 vom: 14. Apr., Seite 302-307 |
| Sprache: |
Chinesisch |
|---|
| Beteiligte Personen: |
Zhang, Y [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Anticoagulants |
|---|
| Anmerkungen: |
Date Completed 26.05.2020 Date Revised 30.11.2021 published: Print CommentIn: J Med Virol. 2021 Jan;93(1):76-77. - PMID 32497287 Citation Status MEDLINE |
|---|
| doi: |
10.3760/cma.j.issn.0253-2727.2020.008 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM310301084 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM310301084 | ||
| 003 | DE-627 | ||
| 005 | 20231225135811.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||chi c | ||
| 024 | 7 | |a 10.3760/cma.j.issn.0253-2727.2020.008 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1034.xml |
| 035 | |a (DE-627)NLM310301084 | ||
| 035 | |a (NLM)32447934 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a chi | ||
| 100 | 1 | |a Zhang, Y |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical and coagulation characteristics in 7 patients with critical COVID-2019 pneumonia and acro-ischemia |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 26.05.2020 | ||
| 500 | |a Date Revised 30.11.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: J Med Virol. 2021 Jan;93(1):76-77. - PMID 32497287 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Objective: To investigate the clinical and coagulation characteristics in patients with critical Coronavirus disease 2019 (COVID-19) and acro-ischemia. Methods: The retrospective study included 7 critical COVID-19 patients with acro-ischemia in an intensive care unit (ICU) in Wuhan, from Feb 4 to Feb 15, 2020. The clinical and laboratory data before and during the ICU stay were analyzed. Results: The median age of 7 patients was 59 years and 4 of them were men. Three patients were associated with underlying comorbidities. Fever, cough, dyspnea and diarrhea were common clinical symptoms. All patients had acro-ischemia presentations including finger/toe cyanosis, skin bulla and dry gangrene. D-dimer, fibrinogen and fibrinogen degradation product (FDP) were significantly elevated in most patients. Prothrombin time was prolonged in 4 patients. D-dimer and FDP levels progressively elevated consistent with COVID-2019 exacerbation. Four patients were diagnosed with disseminated intravascular coagulation (DIC) . Low molecular weight heparin (LMWH) was administrated in 6 patients, which reduced D-dimer and FDP rather than improved clinical symptoms. Five patients died finally and the median time from acro-ischemia to death was 12 days. Conclusions: Coagulation parameters should be monitored closely in critical COVID-2019 patients. The timing and protocol of anticoagulation therapy are still under investigation based on more clinical data | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anticoagulation therapy | |
| 650 | 4 | |a COVID-2019 | |
| 650 | 4 | |a Critical | |
| 650 | 4 | |a Hypercoagulation status | |
| 650 | 7 | |a Anticoagulants |2 NLM | |
| 650 | 7 | |a Fibrin Fibrinogen Degradation Products |2 NLM | |
| 650 | 7 | |a Heparin, Low-Molecular-Weight |2 NLM | |
| 650 | 7 | |a fibrin fragment D |2 NLM | |
| 700 | 1 | |a Cao, W |e verfasserin |4 aut | |
| 700 | 1 | |a Xiao, M |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Y J |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Y |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, J |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, X |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, W |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Y Q |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, S Y |e verfasserin |4 aut | |
| 700 | 1 | |a Li, T S |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi |d 1993 |g 41(2020), 4 vom: 14. Apr., Seite 302-307 |w (DE-627)NLM081873417 |x 0253-2727 |7 nnns |
| 773 | 1 | 8 | |g volume:41 |g year:2020 |g number:4 |g day:14 |g month:04 |g pages:302-307 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.008 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 41 |j 2020 |e 4 |b 14 |c 04 |h 302-307 | ||