Antimicrobial peptide Temporin-L complexed with anionic cyclodextrins results in a potent and safe agent against sessile bacteria
Copyright © 2020 Elsevier B.V. All rights reserved..
Concern over antibiotic resistance is growing, and new classes of antibiotics, particularly against Gram-negative bacteria, are needed. Antimicrobial peptides (AMPs) have been proposed as a new class of clinically useful antimicrobials. Special attention has been devoted to frog-skin temporins. In particular, temporin L (TL) is strongly active against Gram-positive, Gram-negative bacteria and yeast strains. With the aim of overcoming some of the main drawbacks preventing the widespread clinical use of this peptide, i.e. toxicity and unfavorable pharmacokinetics profile, we designed new formulations combining TL with different types of cyclodextrins (CDs). TL was associated to a panel of neutral or negatively charged, monomeric and polymeric CDs. The impact of CDs association on TL solubility, as well as the transport through bacterial alginates was assessed. The biocompatibility on human cells together with the antimicrobial and antibiofilm properties of TL/CD systems was explored.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:584 |
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| Enthalten in: |
International journal of pharmaceutics - 584(2020) vom: 30. Juni, Seite 119437 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Brancaccio, Diego [VerfasserIn] |
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| Links: |
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| Themen: |
Alginates |
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| Anmerkungen: |
Date Completed 23.02.2021 Date Revised 23.02.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijpharm.2020.119437 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310292050 |
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| 245 | 1 | 0 | |a Antimicrobial peptide Temporin-L complexed with anionic cyclodextrins results in a potent and safe agent against sessile bacteria |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier B.V. All rights reserved. | ||
| 520 | |a Concern over antibiotic resistance is growing, and new classes of antibiotics, particularly against Gram-negative bacteria, are needed. Antimicrobial peptides (AMPs) have been proposed as a new class of clinically useful antimicrobials. Special attention has been devoted to frog-skin temporins. In particular, temporin L (TL) is strongly active against Gram-positive, Gram-negative bacteria and yeast strains. With the aim of overcoming some of the main drawbacks preventing the widespread clinical use of this peptide, i.e. toxicity and unfavorable pharmacokinetics profile, we designed new formulations combining TL with different types of cyclodextrins (CDs). TL was associated to a panel of neutral or negatively charged, monomeric and polymeric CDs. The impact of CDs association on TL solubility, as well as the transport through bacterial alginates was assessed. The biocompatibility on human cells together with the antimicrobial and antibiofilm properties of TL/CD systems was explored | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Antibiofilm agents | |
| 650 | 4 | |a Antibiotic resistance | |
| 650 | 4 | |a Antimicrobial peptides | |
| 650 | 4 | |a Cyclodextrins | |
| 650 | 7 | |a Alginates |2 NLM | |
| 650 | 7 | |a Anti-Infective Agents |2 NLM | |
| 650 | 7 | |a Antimicrobial Cationic Peptides |2 NLM | |
| 650 | 7 | |a Cyclodextrins |2 NLM | |
| 650 | 7 | |a temporin |2 NLM | |
| 700 | 1 | |a Pizzo, Elio |e verfasserin |4 aut | |
| 700 | 1 | |a Cafaro, Valeria |e verfasserin |4 aut | |
| 700 | 1 | |a Notomista, Eugenio |e verfasserin |4 aut | |
| 700 | 1 | |a De Lise, Federica |e verfasserin |4 aut | |
| 700 | 1 | |a Bosso, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Gaglione, Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Merlino, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Novellino, Ettore |e verfasserin |4 aut | |
| 700 | 1 | |a Ungaro, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Grieco, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Malanga, Milo |e verfasserin |4 aut | |
| 700 | 1 | |a Quaglia, Fabiana |e verfasserin |4 aut | |
| 700 | 1 | |a Miro, Agnese |e verfasserin |4 aut | |
| 700 | 1 | |a Carotenuto, Alfonso |e verfasserin |4 aut | |
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