Connecting Hydroxychloroquine In Vitro Antiviral Activity to In Vivo Concentration for Prediction of Antiviral Effect : A Critical Step in Treating Patients With Coronavirus Disease 2019
Published by Oxford University Press for the Infectious Diseases Society of America 2020..
Translation of in vitro antiviral activity to the in vivo setting is crucial to identify potentially effective dosing regimens of hydroxychloroquine. In vitro 50%/90% maximal effective concentration values for hydroxychloroquine should be compared to the in vivo free extracellular tissue concentration, which is similar to the free plasma hydroxychloroquine concentration.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:71 |
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| Enthalten in: |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 71(2020), 12 vom: 15. Dez., Seite 3232-3236 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fan, Jianghong [VerfasserIn] |
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| Links: |
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| Themen: |
4QWG6N8QKH |
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| Anmerkungen: |
Date Completed 27.01.2021 Date Revised 07.12.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/cid/ciaa623 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM310181100 |
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| 520 | |a Translation of in vitro antiviral activity to the in vivo setting is crucial to identify potentially effective dosing regimens of hydroxychloroquine. In vitro 50%/90% maximal effective concentration values for hydroxychloroquine should be compared to the in vivo free extracellular tissue concentration, which is similar to the free plasma hydroxychloroquine concentration | ||
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| 700 | 1 | |a Zheng, Nan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Qi |e verfasserin |4 aut | |
| 700 | 1 | |a Bergman, Kimberly |e verfasserin |4 aut | |
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| 700 | 1 | |a Zhu, Hao |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yaning |e verfasserin |4 aut | |
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