Multivalent manganese complex decorated amphiphilic dextran micelles as sensitive MRI probes
T1 contrast agents based on Mn(II) were conjugated on amphiphilic dextran micelles via click chemistry. The obtained paramagnetic nanomicelle contrast agent has a higher T1 relaxivity (13.3 Mn mmol-1 s-1) and better sensitivity than those of free Mn(II) complexes. Studies carried out in vivo suggest that this contrast agent has a better and long-acting vascular enhancement effect at a lower manganese dosage (0.1 Mn mmol kg-1 BW).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:3 |
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| Enthalten in: |
Journal of materials chemistry. B - 3(2015), 8 vom: 28. Feb., Seite 1470-1473 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wu, Changqiang [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Revised 20.05.2020 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/c4tb02036g |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310120403 |
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| 520 | |a T1 contrast agents based on Mn(II) were conjugated on amphiphilic dextran micelles via click chemistry. The obtained paramagnetic nanomicelle contrast agent has a higher T1 relaxivity (13.3 Mn mmol-1 s-1) and better sensitivity than those of free Mn(II) complexes. Studies carried out in vivo suggest that this contrast agent has a better and long-acting vascular enhancement effect at a lower manganese dosage (0.1 Mn mmol kg-1 BW) | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Li, Danyang |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Bingbing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Houbing |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Ye |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Zhuzhong |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Chunchao |e verfasserin |4 aut | |
| 700 | 1 | |a Gong, Qiyong |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Ai, Hua |e verfasserin |4 aut | |
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