Electrochemical and biological characterization of thin-film platinum-iridium alloy electrode coatings : a chronic in vivo study
OBJECTIVE: To evaluate the electrochemical properties, biological response, and surface characterization of an electrodeposited Platinum-Iridium (Pt-Ir) electrode coating on cochlear implants subjected to chronic stimulation in vivo.
APPROACH: Electrochemical impedance spectroscopy (EIS), charge storage capacity (CSC), charge injection limit (CIL), and voltage transient (VT) impedance were measured bench-top before and after implant and in vivo. Coated Pt-Ir and uncoated Pt electrode arrays were implanted into cochlea of normal hearing rats and stimulated for ∼4 h d, 5 d week-1 for 5 weeks at levels within the normal clinical range. Neural function was monitored using electrically-evoked auditory brainstem responses. After explant, the electrode surfaces were assessed, and cochleae examined histologically.
MAIN RESULTS: When measured on bench-top before and after stimulation, Pt-Ir coated electrodes had significantly lower VT impedance (p < 0.001) and significantly higher CSC (p < 0.001) and CIL (p < 0.001) compared to uncoated Pt electrodes. In vivo, the CSC and CIL of Pt-Ir were significantly higher than Pt throughout the implantation period (p= 0.047 and p< 0.001, respectively); however, the VT impedance (p= 0.3) was not. There was no difference in foreign body response between material cohorts, although cochleae implanted with coated electrodes contained small deposits of Pt-Ir. There was no evidence of increased neural loss or loss of neural function in either group. Surface examination revealed no Pt corrosion on any electrodes.
SIGNIFICANCE: Electrodeposited Pt-Ir electrodes demonstrated significant improvements in electrochemical performance on the bench-top and in vivo compared to uncoated Pt. Neural function and tissue response to Pt-Ir electrodes were not different from uncoated Pt, despite small deposits of Pt-Ir in the tissue capsule. Electrodeposited Pt-Ir coatings offer promise as an improved electrode coating for active neural prostheses.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Journal of neural engineering - 17(2020), 3 vom: 22. Juni, Seite 036012 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dalrymple, Ashley N [VerfasserIn] |
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| Links: |
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| Themen: |
37186-87-1 |
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| Anmerkungen: |
Date Completed 25.06.2021 Date Revised 25.06.2021 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1088/1741-2552/ab933d |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM309910749 |
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| 100 | 1 | |a Dalrymple, Ashley N |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Electrochemical and biological characterization of thin-film platinum-iridium alloy electrode coatings |b a chronic in vivo study |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Revised 25.06.2021 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To evaluate the electrochemical properties, biological response, and surface characterization of an electrodeposited Platinum-Iridium (Pt-Ir) electrode coating on cochlear implants subjected to chronic stimulation in vivo | ||
| 520 | |a APPROACH: Electrochemical impedance spectroscopy (EIS), charge storage capacity (CSC), charge injection limit (CIL), and voltage transient (VT) impedance were measured bench-top before and after implant and in vivo. Coated Pt-Ir and uncoated Pt electrode arrays were implanted into cochlea of normal hearing rats and stimulated for ∼4 h d, 5 d week-1 for 5 weeks at levels within the normal clinical range. Neural function was monitored using electrically-evoked auditory brainstem responses. After explant, the electrode surfaces were assessed, and cochleae examined histologically | ||
| 520 | |a MAIN RESULTS: When measured on bench-top before and after stimulation, Pt-Ir coated electrodes had significantly lower VT impedance (p < 0.001) and significantly higher CSC (p < 0.001) and CIL (p < 0.001) compared to uncoated Pt electrodes. In vivo, the CSC and CIL of Pt-Ir were significantly higher than Pt throughout the implantation period (p= 0.047 and p< 0.001, respectively); however, the VT impedance (p= 0.3) was not. There was no difference in foreign body response between material cohorts, although cochleae implanted with coated electrodes contained small deposits of Pt-Ir. There was no evidence of increased neural loss or loss of neural function in either group. Surface examination revealed no Pt corrosion on any electrodes | ||
| 520 | |a SIGNIFICANCE: Electrodeposited Pt-Ir electrodes demonstrated significant improvements in electrochemical performance on the bench-top and in vivo compared to uncoated Pt. Neural function and tissue response to Pt-Ir electrodes were not different from uncoated Pt, despite small deposits of Pt-Ir in the tissue capsule. Electrodeposited Pt-Ir coatings offer promise as an improved electrode coating for active neural prostheses | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a platinum-iridium alloy |2 NLM | |
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| 700 | 1 | |a Huynh, Mario |e verfasserin |4 aut | |
| 700 | 1 | |a Nayagam, Bryony A |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Curtis D |e verfasserin |4 aut | |
| 700 | 1 | |a Weiland, Greg R |e verfasserin |4 aut | |
| 700 | 1 | |a Petrossians, Artin |e verfasserin |4 aut | |
| 700 | 1 | |a J, John |e verfasserin |4 aut | |
| 700 | 1 | |a Iii, Whalen |e verfasserin |4 aut | |
| 700 | 1 | |a Fallon, James B |e verfasserin |4 aut | |
| 700 | 1 | |a Shepherd, Robert K |e verfasserin |4 aut | |
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