Risk Factors for Severe Disease and Efficacy of Treatment in Patients Infected With COVID-19 : A Systematic Review, Meta-Analysis, and Meta-Regression Analysis
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America..
The coronavirus disease 2019 (COVID-19) pandemic spread globally in the beginning of 2020. At present, predictors of severe disease and the efficacy of different treatments are not well understood. We conducted a systematic review and meta-analysis of all published studies up to 15 March 2020, which reported COVID-19 clinical features and/or treatment outcomes. Forty-five studies reporting 4203 patients were included. Pooled rates of intensive care unit (ICU) admission, mortality, and acute respiratory distress syndrome (ARDS) were 10.9%, 4.3%, and 18.4%, respectively. On meta-regression, ICU admission was predicted by increased leukocyte count (P < .0001), alanine aminotransferase (P = .024), and aspartate transaminase (P = .0040); elevated lactate dehydrogenase (LDH) (P < .0001); and increased procalcitonin (P < .0001). ARDS was predicted by elevated LDH (P < .0001), while mortality was predicted by increased leukocyte count (P = .0005) and elevated LDH (P < .0001). Treatment with lopinavir-ritonavir showed no significant benefit in mortality and ARDS rates. Corticosteroids were associated with a higher rate of ARDS (P = .0003).
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2020 |
---|---|
Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:71 |
---|---|
Enthalten in: |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 71(2020), 16 vom: 19. Nov., Seite 2199-2206 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Zhang, John J Y [VerfasserIn] |
---|
Links: |
---|
Themen: |
Adrenal Cortex Hormones |
---|
Anmerkungen: |
Date Completed 04.12.2020 Date Revised 04.11.2023 published: Print Citation Status MEDLINE |
---|
doi: |
10.1093/cid/ciaa576 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM309902657 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM309902657 | ||
003 | DE-627 | ||
005 | 20231225134926.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2020 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1093/cid/ciaa576 |2 doi | |
028 | 5 | 2 | |a pubmed24n1032.xml |
035 | |a (DE-627)NLM309902657 | ||
035 | |a (NLM)32407459 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Zhang, John J Y |e verfasserin |4 aut | |
245 | 1 | 0 | |a Risk Factors for Severe Disease and Efficacy of Treatment in Patients Infected With COVID-19 |b A Systematic Review, Meta-Analysis, and Meta-Regression Analysis |
264 | 1 | |c 2020 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 04.12.2020 | ||
500 | |a Date Revised 04.11.2023 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. | ||
520 | |a The coronavirus disease 2019 (COVID-19) pandemic spread globally in the beginning of 2020. At present, predictors of severe disease and the efficacy of different treatments are not well understood. We conducted a systematic review and meta-analysis of all published studies up to 15 March 2020, which reported COVID-19 clinical features and/or treatment outcomes. Forty-five studies reporting 4203 patients were included. Pooled rates of intensive care unit (ICU) admission, mortality, and acute respiratory distress syndrome (ARDS) were 10.9%, 4.3%, and 18.4%, respectively. On meta-regression, ICU admission was predicted by increased leukocyte count (P < .0001), alanine aminotransferase (P = .024), and aspartate transaminase (P = .0040); elevated lactate dehydrogenase (LDH) (P < .0001); and increased procalcitonin (P < .0001). ARDS was predicted by elevated LDH (P < .0001), while mortality was predicted by increased leukocyte count (P = .0005) and elevated LDH (P < .0001). Treatment with lopinavir-ritonavir showed no significant benefit in mortality and ARDS rates. Corticosteroids were associated with a higher rate of ARDS (P = .0003) | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Meta-Analysis | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Systematic Review | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a coronavirus | |
650 | 4 | |a risk factor | |
650 | 4 | |a severe | |
650 | 4 | |a treatment | |
650 | 7 | |a Adrenal Cortex Hormones |2 NLM | |
650 | 7 | |a Ritonavir |2 NLM | |
650 | 7 | |a O3J8G9O825 |2 NLM | |
700 | 1 | |a Lee, Keng Siang |e verfasserin |4 aut | |
700 | 1 | |a Ang, Li Wei |e verfasserin |4 aut | |
700 | 1 | |a Leo, Yee Sin |e verfasserin |4 aut | |
700 | 1 | |a Young, Barnaby Edward |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |d 1992 |g 71(2020), 16 vom: 19. Nov., Seite 2199-2206 |w (DE-627)NLM012603007 |x 1537-6591 |7 nnns |
773 | 1 | 8 | |g volume:71 |g year:2020 |g number:16 |g day:19 |g month:11 |g pages:2199-2206 |
856 | 4 | 0 | |u http://dx.doi.org/10.1093/cid/ciaa576 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 71 |j 2020 |e 16 |b 19 |c 11 |h 2199-2206 |