Simultaneous determination of nine perfluoroalkyl carboxylic acids by a series of amide acetals derivatization and gas chromatography tandem mass spectrometry
Copyright © 2020 Elsevier B.V. All rights reserved..
A novel and simple derivatization method using a series of amide acetals as derivatization reagents, along with gas chromatography tandem mass spectrometry (GC-MS/MS) analysis, were developed and validated for simultaneous determination of 9 perfluoroalkyl carboxylic acids (PFCAs) in this study. The structures and fragmentation pathway of PFCAs derivatives were deduced and verified. The derivatization method developed in this study improved the sensitivity of the detection of PFCAs by GC. The applicability of 6 amide acetals for the derivatization of PFCAs was demonstrated. Derivatization conditions for 9 PFCAs were optimized with addition of 20 μL of derivatization reagent and reaction at 35 °C for 30 min. 9 PFCAs derivatives were confirmed to be stable over 15 days. The instrument detection limits (IDLs) were lower than 0.01 pg/μL. The intra and inter-day precisions were below 4.06% and 5.48%, respectively. To demonstrate the utility of the derivatization method, the level of PFCAs in the marine products were detected. The alkaline digestion followed by solid-phase extraction (SPE) cleanup method was used for pretreatment. The method detection limits (MDLs) ranged from 0.04 to 0.10 ng/g, and the spiked recoveries ranged between 54.72% and 107.29%, with relative standard deviation (RSD) of 1.53%-11.89%. Five PFCAs were detected in the range of 0.66 to 499.03 ng/g dry weight.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:1622 |
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| Enthalten in: |
Journal of chromatography. A - 1622(2020) vom: 05. Juli, Seite 461132 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ji, Yongyan [VerfasserIn] |
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| Links: |
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| Themen: |
8696NH0Y2X |
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| Anmerkungen: |
Date Completed 29.07.2020 Date Revised 29.07.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.chroma.2020.461132 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM309854636 |
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| 245 | 1 | 0 | |a Simultaneous determination of nine perfluoroalkyl carboxylic acids by a series of amide acetals derivatization and gas chromatography tandem mass spectrometry |
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| 520 | |a Copyright © 2020 Elsevier B.V. All rights reserved. | ||
| 520 | |a A novel and simple derivatization method using a series of amide acetals as derivatization reagents, along with gas chromatography tandem mass spectrometry (GC-MS/MS) analysis, were developed and validated for simultaneous determination of 9 perfluoroalkyl carboxylic acids (PFCAs) in this study. The structures and fragmentation pathway of PFCAs derivatives were deduced and verified. The derivatization method developed in this study improved the sensitivity of the detection of PFCAs by GC. The applicability of 6 amide acetals for the derivatization of PFCAs was demonstrated. Derivatization conditions for 9 PFCAs were optimized with addition of 20 μL of derivatization reagent and reaction at 35 °C for 30 min. 9 PFCAs derivatives were confirmed to be stable over 15 days. The instrument detection limits (IDLs) were lower than 0.01 pg/μL. The intra and inter-day precisions were below 4.06% and 5.48%, respectively. To demonstrate the utility of the derivatization method, the level of PFCAs in the marine products were detected. The alkaline digestion followed by solid-phase extraction (SPE) cleanup method was used for pretreatment. The method detection limits (MDLs) ranged from 0.04 to 0.10 ng/g, and the spiked recoveries ranged between 54.72% and 107.29%, with relative standard deviation (RSD) of 1.53%-11.89%. Five PFCAs were detected in the range of 0.66 to 499.03 ng/g dry weight | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Amide acetals | |
| 650 | 4 | |a Derivatization | |
| 650 | 4 | |a Gas chromatography tandem mass spectrometry | |
| 650 | 4 | |a Perfluoroalkyl carboxylic acids | |
| 650 | 7 | |a Acetals |2 NLM | |
| 650 | 7 | |a Amides |2 NLM | |
| 650 | 7 | |a Carboxylic Acids |2 NLM | |
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| 700 | 1 | |a Li, Xuemin |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Zhibin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jinjie |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Adan |e verfasserin |4 aut | |
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