NEUROFIBROMATOSIS TYPE 1 AND OPTIC PATHWAY GLIOMA
PURPOSE: Evaluate the effectiveness of treatment of patients with optic pathway glioma.
MATERIALS AND METHODS: Comparison of literature research on neurofibromatosis and optic pathway glioma with a cohort of pediatric patients treated at the Childrens Ophthalmology Clinic of the University Hospital in Brno from January 2013 until June 2018.
DISCUSSION: The main challenge of this and other retrospective studies is variable intervals between ophthalmologic examinations. In some pediatric patients it is also difficult to objectively assess visual functions. The main risk factors are age at the time of treatment and tumor localization. Tumor progression itself does not always correlate with worse visual acuity outcomes, and it remains to be evaluated whether some patients would be better off without treatment. As of now, there are no clinical biomarkers able to predict impending visual acuity loss.
CONCLUSION: The cohort outcome agrees with literature. Chemotherapy remains a treatment of choice and its most likely outcome is visual acuity stabilization. In order to properly evaluate the treatments effectiveness, better collaboration between medical specialists and regular standardized ophthalmology examinations are required.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
|---|---|
| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:75 |
|---|---|
| Enthalten in: |
Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti - 75(2019), 4 vom: 05., Seite 200-208 |
| Sprache: |
Englisch |
|---|
| Weiterer Titel: |
NEUROFIBROMATÓZA 1. TYPU A GLIOM OPTIKU |
|---|
| Beteiligte Personen: |
Siwá, A [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Chemotherapy |
|---|
| Anmerkungen: |
Date Completed 30.06.2020 Date Revised 30.06.2020 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.31348/2019/4/4 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM309807778 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM309807778 | ||
| 003 | DE-627 | ||
| 005 | 20231225134726.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.31348/2019/4/4 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1032.xml |
| 035 | |a (DE-627)NLM309807778 | ||
| 035 | |a (NLM)32397722 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Siwá, A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a NEUROFIBROMATOSIS TYPE 1 AND OPTIC PATHWAY GLIOMA |
| 246 | 3 | 3 | |a NEUROFIBROMATÓZA 1. TYPU A GLIOM OPTIKU |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 30.06.2020 | ||
| 500 | |a Date Revised 30.06.2020 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: Evaluate the effectiveness of treatment of patients with optic pathway glioma | ||
| 520 | |a MATERIALS AND METHODS: Comparison of literature research on neurofibromatosis and optic pathway glioma with a cohort of pediatric patients treated at the Childrens Ophthalmology Clinic of the University Hospital in Brno from January 2013 until June 2018 | ||
| 520 | |a DISCUSSION: The main challenge of this and other retrospective studies is variable intervals between ophthalmologic examinations. In some pediatric patients it is also difficult to objectively assess visual functions. The main risk factors are age at the time of treatment and tumor localization. Tumor progression itself does not always correlate with worse visual acuity outcomes, and it remains to be evaluated whether some patients would be better off without treatment. As of now, there are no clinical biomarkers able to predict impending visual acuity loss | ||
| 520 | |a CONCLUSION: The cohort outcome agrees with literature. Chemotherapy remains a treatment of choice and its most likely outcome is visual acuity stabilization. In order to properly evaluate the treatments effectiveness, better collaboration between medical specialists and regular standardized ophthalmology examinations are required | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a chemotherapy | |
| 650 | 4 | |a children | |
| 650 | 4 | |a neurofibromatosis | |
| 650 | 4 | |a optic pathway glioma | |
| 650 | 4 | |a treatment | |
| 700 | 1 | |a Autrata, R |e verfasserin |4 aut | |
| 700 | 1 | |a Vejmělková, K |e verfasserin |4 aut | |
| 700 | 1 | |a Pavelka, Z |e verfasserin |4 aut | |
| 700 | 1 | |a Zitterbart, K |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti |d 1998 |g 75(2019), 4 vom: 05., Seite 200-208 |w (DE-627)NLM075622777 |x 1211-9059 |7 nnns |
| 773 | 1 | 8 | |g volume:75 |g year:2019 |g number:4 |g day:05 |g pages:200-208 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.31348/2019/4/4 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 75 |j 2019 |e 4 |b 05 |h 200-208 | ||