Cardioprotective effects of timosaponin B-II isolated from Anemarrhena rhizome in a zebrafish model
Timosaponin B-II (TB-II; (25S)-26-(β-D-glucopyranosyloxy)-3β-[(2-O-β-D-glucopyranosyl-β-D-galactopyranosyl) oxy]-5β-furostan-22-ol is extracted from Anemarrhena. Its anti-inflammation, anti-oxidation, and anti-asthma properties have been widely explored. However, its effect on the heart has not been reported. In this study, we used zebrafish as a research model to determine the effects of TB-II on the heart and its toxic and anti-inflammatory effects. To explore the cause of cardioprotective effects of TB-II, we used transgenic zebrafish with macrophages and neutrophils labeled with fluorescent protein. We found for the first time that TB-II had a protective effect on the zebrafish heart. It did not affect the survival and hatching rates of zebrafish embryos, indicating its low toxicity. Results showed that TB-II may have cardioprotective effects, which might be related to its anti-inflammatory effects.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:75 |
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| Enthalten in: |
Die Pharmazie - 75(2020), 5 vom: 01. Mai, Seite 201-204 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Du, Meng-Jiao [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Inflammatory Agents |
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| Anmerkungen: |
Date Completed 22.04.2021 Date Revised 22.04.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1691/ph.2020.9869 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM309765854 |
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| 520 | |a Timosaponin B-II (TB-II; (25S)-26-(β-D-glucopyranosyloxy)-3β-[(2-O-β-D-glucopyranosyl-β-D-galactopyranosyl) oxy]-5β-furostan-22-ol is extracted from Anemarrhena. Its anti-inflammation, anti-oxidation, and anti-asthma properties have been widely explored. However, its effect on the heart has not been reported. In this study, we used zebrafish as a research model to determine the effects of TB-II on the heart and its toxic and anti-inflammatory effects. To explore the cause of cardioprotective effects of TB-II, we used transgenic zebrafish with macrophages and neutrophils labeled with fluorescent protein. We found for the first time that TB-II had a protective effect on the zebrafish heart. It did not affect the survival and hatching rates of zebrafish embryos, indicating its low toxicity. Results showed that TB-II may have cardioprotective effects, which might be related to its anti-inflammatory effects | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Cardiotonic Agents |2 NLM | |
| 650 | 7 | |a Saponins |2 NLM | |
| 650 | 7 | |a Steroids |2 NLM | |
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| 700 | 1 | |a Lian, Bo-Wen |e verfasserin |4 aut | |
| 700 | 1 | |a Mei, Wen-Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Jia-Xian |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Li-Shi |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Shan-Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhong, Yan-Mei |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Chu-Qin |e verfasserin |4 aut | |
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