Hydroxychloroquine in Coronavirus Disease 2019 Patients : What Still Needs to Be Known About the Kinetics

© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com..

Different dosage regimens of hydroxychloroquine are used to manage coronavirus disease 2019 (COVID-19) patients, without information on the pharmacokinetics in this population. Blood samples (n = 101) were collected from 57 COVID-19 patients for 7 days, and concentrations were compared with simulated kinetic profiles. Hydroxychloroquine exposure is low and cannot be predicted by other populations.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:71

Enthalten in:

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 71(2020), 11 vom: 31. Dez., Seite 2962-2964

Sprache:

Englisch

Beteiligte Personen:

Martin-Blondel, Guillaume [VerfasserIn]
Ruiz, Stéphanie [VerfasserIn]
Murris, Marlène [VerfasserIn]
Faguer, Stanilas [VerfasserIn]
Duhalde, Véronigue [VerfasserIn]
Eyvrard, Frédéric [VerfasserIn]
Izopet, Jacques [VerfasserIn]
Mansuy, Jean-Michel [VerfasserIn]
Rolland, Yves [VerfasserIn]
Delavigne, Karen [VerfasserIn]
Guimbaud, Rosine [VerfasserIn]
Pugnet, Grégory [VerfasserIn]
Conil, Jean-Marie [VerfasserIn]
Georges, Bernard [VerfasserIn]
Delobel, Pierre [VerfasserIn]
Minville, Vincent [VerfasserIn]
Silva Sifontes, Stein [VerfasserIn]
Concordet, Didier [VerfasserIn]
Gandia, Peggy [VerfasserIn]

Links:

Volltext

Themen:

4QWG6N8QKH
Antiviral Agents
COVID-19
Dosage regimens
Drug monitoring
Hydroxychloroquine
Journal Article
Population pharmacokinetic modeling

Anmerkungen:

Date Completed 06.01.2021

Date Revised 07.12.2022

published: Print

Citation Status MEDLINE

doi:

10.1093/cid/ciaa558

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM309754941