A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC..
Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of these findings for cancer and chemoresistance development.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
Molecular & cellular oncology - 7(2020), 3 vom: 15., Seite 1733383 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Milanese, Chiara [VerfasserIn] |
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| Links: |
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| Themen: |
DNA damage |
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| Anmerkungen: |
Date Revised 07.05.2021 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1080/23723556.2020.1733383 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM309746124 |
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| 520 | |a Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of these findings for cancer and chemoresistance development | ||
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