Implementation of a pharmacogenomic program in a Brazilian public institution
This narrative review describes implementation, current status and perspectives of a pharmacogenomic (PGx) program at the Brazilian National Cancer Institute (INCA), targeting the cancer chemotherapeutic drugs - fluoropyrimidines, irinotecan and thiopurines. This initiative, designed as a research project, was supported by a grant from the Brazilian Ministry of Health. A dedicated task force developed standard operational procedures from recruitment of patients to creating PGx reports with dosing recommendations, which were successfully applied to test 100 gastrointestinal cancer INCA outpatients and 162 acute lymphoblastic leukemia pediatric patients from INCA and seven other hospitals. The program has been subsequently expanded to include gastrointestinal cancer patients from three additional cancer treatment centers. We anticipate implementation of routine pre-emptive PGx testing at INCA but acknowledge challenges associated with this transition, such as continuous financing support, availability of trained personnel, adoption of the PGx-informed prescription by the clinical staff and, ultimately, evidence of cost-effectiveness.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
|---|---|
| Enthalten in: |
Pharmacogenomics - 21(2020), 8 vom: 01. Juni, Seite 549-557 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Suarez-Kurtz, Guilherme [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Antineoplastic Agents |
|---|
| Anmerkungen: |
Date Completed 26.04.2021 Date Revised 26.04.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.2217/pgs-2020-0016 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM309623162 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM309623162 | ||
| 003 | DE-627 | ||
| 005 | 20231225134325.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2217/pgs-2020-0016 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1032.xml |
| 035 | |a (DE-627)NLM309623162 | ||
| 035 | |a (NLM)32378980 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Suarez-Kurtz, Guilherme |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Implementation of a pharmacogenomic program in a Brazilian public institution |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 26.04.2021 | ||
| 500 | |a Date Revised 26.04.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a This narrative review describes implementation, current status and perspectives of a pharmacogenomic (PGx) program at the Brazilian National Cancer Institute (INCA), targeting the cancer chemotherapeutic drugs - fluoropyrimidines, irinotecan and thiopurines. This initiative, designed as a research project, was supported by a grant from the Brazilian Ministry of Health. A dedicated task force developed standard operational procedures from recruitment of patients to creating PGx reports with dosing recommendations, which were successfully applied to test 100 gastrointestinal cancer INCA outpatients and 162 acute lymphoblastic leukemia pediatric patients from INCA and seven other hospitals. The program has been subsequently expanded to include gastrointestinal cancer patients from three additional cancer treatment centers. We anticipate implementation of routine pre-emptive PGx testing at INCA but acknowledge challenges associated with this transition, such as continuous financing support, availability of trained personnel, adoption of the PGx-informed prescription by the clinical staff and, ultimately, evidence of cost-effectiveness | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a DPYD | |
| 650 | 4 | |a NUDT15 | |
| 650 | 4 | |a TPMT | |
| 650 | 4 | |a UGT1A1 | |
| 650 | 4 | |a cancer pharmacogenomics | |
| 650 | 4 | |a fluoropyrimidines | |
| 650 | 4 | |a irinotecan | |
| 650 | 4 | |a thiopurines | |
| 650 | 7 | |a Antineoplastic Agents |2 NLM | |
| 700 | 1 | |a Kovaleski, Giovana |e verfasserin |4 aut | |
| 700 | 1 | |a Elias, Anna Br |e verfasserin |4 aut | |
| 700 | 1 | |a Motta, Vera LA |e verfasserin |4 aut | |
| 700 | 1 | |a Wolch, Karolyne |e verfasserin |4 aut | |
| 700 | 1 | |a Emerenciano, Mariana |e verfasserin |4 aut | |
| 700 | 1 | |a Mansur, Marcela B |e verfasserin |4 aut | |
| 700 | 1 | |a Palladino, Alexandre M |e verfasserin |4 aut | |
| 700 | 1 | |a Accioly, Maria T |e verfasserin |4 aut | |
| 700 | 1 | |a Ferreira, Marcos |e verfasserin |4 aut | |
| 700 | 1 | |a Gonçalves, Antonio A |e verfasserin |4 aut | |
| 700 | 1 | |a de Melo, Andréia C |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pharmacogenomics |d 2000 |g 21(2020), 8 vom: 01. Juni, Seite 549-557 |w (DE-627)NLM111671396 |x 1744-8042 |7 nnns |
| 773 | 1 | 8 | |g volume:21 |g year:2020 |g number:8 |g day:01 |g month:06 |g pages:549-557 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2217/pgs-2020-0016 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 21 |j 2020 |e 8 |b 01 |c 06 |h 549-557 | ||