A Cross-Sectional Study of Seroprevalence of Strongyloidiasis in Pregnant Women (Peruvian Amazon Basin)
Strongyloidiasis is a soil-transmitted helminthiasis with a high global prevalence.
OBJECTIVES: We aimed to evaluate the prevalence of Strongyloides stercoralis infection and assess strongyloidiasis serology as a screening technique in the Peruvian Amazon.
MATERIAL AND METHODS: We performed a cross-sectional study of strongyloidiasis in 300 pregnant women in Iquitos (Peru) from 1 May 2019 to 15 June 2019. Women were tested using serology (Strongyloides IgG IVD-ELISA kit) as an index test and the modified Baermann technique and/or charcoal fecal culture as the parasitological reference standard.
RESULTS: The reference tests showed S. stercoralis in the stool of 30 women (prevalence: 10%; 95% confidence interval [CI] 7.1% to 13.9%), while 101 women tested positive on the blood test (prevalence: 33.7%; 95% CI 28.6% to 39.4%). Fourteen of the 15 women (93.3%) with positive results according to the modified Baermann technique, and 14 of the 23 women (56.5%) with positive charcoal cultures also had positive serological results. Serology showed a sensitivity of 63.3% and a negative predictive value of 94.4%.
CONCLUSION: In Iquitos, pregnant women have a high prevalence of S stercoralis. S. stercoralis ELISA could be an excellent tool for population-based screening, as it has a high negative predictive value that can help to rule out the presence of active infection.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Pathogens (Basel, Switzerland) - 9(2020), 5 vom: 04. Mai |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ortiz-Martínez, Sonia [VerfasserIn] |
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| Links: |
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| Themen: |
Amazon |
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| Anmerkungen: |
Date Revised 28.09.2020 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/pathogens9050348 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM309587042 |
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| 100 | 1 | |a Ortiz-Martínez, Sonia |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A Cross-Sectional Study of Seroprevalence of Strongyloidiasis in Pregnant Women (Peruvian Amazon Basin) |
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| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Strongyloidiasis is a soil-transmitted helminthiasis with a high global prevalence | ||
| 520 | |a OBJECTIVES: We aimed to evaluate the prevalence of Strongyloides stercoralis infection and assess strongyloidiasis serology as a screening technique in the Peruvian Amazon | ||
| 520 | |a MATERIAL AND METHODS: We performed a cross-sectional study of strongyloidiasis in 300 pregnant women in Iquitos (Peru) from 1 May 2019 to 15 June 2019. Women were tested using serology (Strongyloides IgG IVD-ELISA kit) as an index test and the modified Baermann technique and/or charcoal fecal culture as the parasitological reference standard | ||
| 520 | |a RESULTS: The reference tests showed S. stercoralis in the stool of 30 women (prevalence: 10%; 95% confidence interval [CI] 7.1% to 13.9%), while 101 women tested positive on the blood test (prevalence: 33.7%; 95% CI 28.6% to 39.4%). Fourteen of the 15 women (93.3%) with positive results according to the modified Baermann technique, and 14 of the 23 women (56.5%) with positive charcoal cultures also had positive serological results. Serology showed a sensitivity of 63.3% and a negative predictive value of 94.4% | ||
| 520 | |a CONCLUSION: In Iquitos, pregnant women have a high prevalence of S stercoralis. S. stercoralis ELISA could be an excellent tool for population-based screening, as it has a high negative predictive value that can help to rule out the presence of active infection | ||
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| 650 | 4 | |a Strongyloides stercoralis | |
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| 650 | 4 | |a serology | |
| 650 | 4 | |a seroprevalence | |
| 700 | 1 | |a Ramos-Rincón, José-Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Vásquez-Chasnamote, María-Esteyner |e verfasserin |4 aut | |
| 700 | 1 | |a Alarcón-Baldeón, Jhonatan J |e verfasserin |4 aut | |
| 700 | 1 | |a Parraguez-de-la-Cruz, Jorge |e verfasserin |4 aut | |
| 700 | 1 | |a Gamboa-Paredes, Olga-Nohelia |e verfasserin |4 aut | |
| 700 | 1 | |a Schillyk-Guerra, Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Espinoza-Venegas, Luis-Alfredo |e verfasserin |4 aut | |
| 700 | 1 | |a Pinedo-Cancino, Viviana-Vanessa |e verfasserin |4 aut | |
| 700 | 1 | |a Perez-Tanoira, Ramón |e verfasserin |4 aut | |
| 700 | 1 | |a Górgolas-Hernández-Mora, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Casapía-Morales, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Spanish-Peruvian Chagas Htlv And Strongyloides Network |e verfasserin |4 aut | |
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