Efficient sub-15 nm cubic-phase core/shell upconversion nanoparticles as reporters for ensemble and single particle studies
Single particle imaging of upconversion nanoparticles (UCNPs) has typically been realized using hexagonal (β) phase lanthanide-doped sodium yttrium fluoride (NaYF4) materials, the upconversion luminescence (UCL) of which saturates at power densities (P) of several hundred W cm-2 under 980 nm near-infrared (NIR) excitation. Cubic (α) phase UCNPs have been mostly neglected because of their commonly observed lower UCL efficiency at comparable P in ensemble level studies. Here, we describe a set of sub-15 nm ytterbium-enriched α-NaYbF4:Er3+CaF2 core/shell UCNPs doped with varying Er3+ concentrations (5-25%), studied over a wide P range of ∼8-105 W cm-2, which emit intense UCL even at a low P of 10 W cm-2 and also saturate at relatively low P. The highest upconversion quantum yield (ΦUC) and the highest particle brightness were obtained for an Er3+ dopant concentration of 12%, reaching the highest ΦUC of 0.77% at a saturation power density (Psat) of 110 W cm-2. These 12%Er3+-doped core/shell UCNPs were also the brightest UCNPs among this series under microscopic conditions at high P of ∼102-105 W cm-2 as demonstrated by imaging studies at the single particle level. Our results underline the potential applicability of the described sub-15 nm cubic-phase core/shell UCNPs for ensemble- and single particle-level bioimaging.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Nanoscale - 12(2020), 19 vom: 21. Mai, Seite 10592-10599 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tan, Meiling [VerfasserIn] |
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| Anmerkungen: |
Date Revised 21.05.2020 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/d0nr02172e |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM309572819 |
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| 520 | |a Single particle imaging of upconversion nanoparticles (UCNPs) has typically been realized using hexagonal (β) phase lanthanide-doped sodium yttrium fluoride (NaYF4) materials, the upconversion luminescence (UCL) of which saturates at power densities (P) of several hundred W cm-2 under 980 nm near-infrared (NIR) excitation. Cubic (α) phase UCNPs have been mostly neglected because of their commonly observed lower UCL efficiency at comparable P in ensemble level studies. Here, we describe a set of sub-15 nm ytterbium-enriched α-NaYbF4:Er3+CaF2 core/shell UCNPs doped with varying Er3+ concentrations (5-25%), studied over a wide P range of ∼8-105 W cm-2, which emit intense UCL even at a low P of 10 W cm-2 and also saturate at relatively low P. The highest upconversion quantum yield (ΦUC) and the highest particle brightness were obtained for an Er3+ dopant concentration of 12%, reaching the highest ΦUC of 0.77% at a saturation power density (Psat) of 110 W cm-2. These 12%Er3+-doped core/shell UCNPs were also the brightest UCNPs among this series under microscopic conditions at high P of ∼102-105 W cm-2 as demonstrated by imaging studies at the single particle level. Our results underline the potential applicability of the described sub-15 nm cubic-phase core/shell UCNPs for ensemble- and single particle-level bioimaging | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Monks, Melissa-Jane |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Dingxin |e verfasserin |4 aut | |
| 700 | 1 | |a Meng, Yongjun |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Xuewen |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Lim, Shuang-Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Würth, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Resch-Genger, Ute |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Guanying |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:12 |g year:2020 |g number:19 |g day:21 |g month:05 |g pages:10592-10599 |
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