Distinct cellular immune properties in cerebrospinal fluid are associated with cognition in HIV-infected individuals initiating antiretroviral therapy
Copyright © 2020 Elsevier B.V. All rights reserved..
We examined the relationship between CSF immune cells and neurocognition and neuronal damage in HIV+ individuals before and after initiating antiretroviral therapy. Multivariate analysis at baseline indicated that greater CD4+ T cell abundance was associated with better cognition (p = .017), while higher CSF HIV RNA was associated with increased neuronal damage (p = .014). Following 24 weeks of antiretroviral therapy, CD8+ T cells, HLA-DR expressing CD4+ and CD8+ T cells, B cells, NK cells, and non-classical monocyte percentage decreased in CSF. Female gender was negatively associated with cognitive performance over time, as was higher percentage of HLA-DR expressing CD8+ T cells at baseline.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:344 |
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| Enthalten in: |
Journal of neuroimmunology - 344(2020) vom: 15. Juli, Seite 577246 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Amundson, Beret [VerfasserIn] |
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| Links: |
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| Themen: |
AIDS |
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| Anmerkungen: |
Date Completed 11.11.2020 Date Revised 16.12.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jneuroim.2020.577246 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM309546699 |
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| 245 | 1 | 0 | |a Distinct cellular immune properties in cerebrospinal fluid are associated with cognition in HIV-infected individuals initiating antiretroviral therapy |
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| 500 | |a Date Revised 16.12.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier B.V. All rights reserved. | ||
| 520 | |a We examined the relationship between CSF immune cells and neurocognition and neuronal damage in HIV+ individuals before and after initiating antiretroviral therapy. Multivariate analysis at baseline indicated that greater CD4+ T cell abundance was associated with better cognition (p = .017), while higher CSF HIV RNA was associated with increased neuronal damage (p = .014). Following 24 weeks of antiretroviral therapy, CD8+ T cells, HLA-DR expressing CD4+ and CD8+ T cells, B cells, NK cells, and non-classical monocyte percentage decreased in CSF. Female gender was negatively associated with cognitive performance over time, as was higher percentage of HLA-DR expressing CD8+ T cells at baseline | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a AIDS | |
| 650 | 4 | |a Cerebrospinal fluid | |
| 650 | 4 | |a Cognition | |
| 650 | 4 | |a Flow cytometry | |
| 650 | 4 | |a HIV | |
| 700 | 1 | |a Lai, Lillin |e verfasserin |4 aut | |
| 700 | 1 | |a Mulligan, Mark J |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Zidou |e verfasserin |4 aut | |
| 700 | 1 | |a Kundu, Suprateek |e verfasserin |4 aut | |
| 700 | 1 | |a Lennox, Jeffrey L |e verfasserin |4 aut | |
| 700 | 1 | |a Waldrop-Valverde, Drenna |e verfasserin |4 aut | |
| 700 | 1 | |a Franklin, Donald |e verfasserin |4 aut | |
| 700 | 1 | |a Swaims-Kohlmeier, Alison |e verfasserin |4 aut | |
| 700 | 1 | |a Letendre, Scott L |e verfasserin |4 aut | |
| 700 | 1 | |a Anderson, Albert M |e verfasserin |4 aut | |
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