Progressive multifocal leukoencephalopathy presenting with acute sensorineural hearing loss in an intestinal transplant recipient
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd..
A 20-year-old male presented 3.5 years after intestinal transplantation with rapidly progressive sensorineural hearing loss. Initial brain imaging was consistent with inflammation and/or demyelination. Lumbar puncture was initially non-diagnostic and a broad infectious workup was unrevealing. Three months after presentation, a repeat LP detected JC virus for which tests had not earlier been conducted. He continued to deteriorate despite withdrawal of prior immunosuppression and addition of mirtazapine, maraviroc, and steroids. He died of progressive neurologic decompensation 5 months after his initial presentation. This case highlights progressive multifocal leukoencephalopathy (PML) as a rare complication after solid organ transplantation and acute sensorineural hearing loss as an unusual first presenting symptom of PML. JC virus should be considered in the differential diagnosis of acute sensorineural hearing loss in any immunocompromised patient.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Transplant infectious disease : an official journal of the Transplantation Society - 22(2020), 4 vom: 10. Aug., Seite e13304 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lippa, Andrew M [VerfasserIn] |
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| Links: |
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| Themen: |
Case Reports |
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| Anmerkungen: |
Date Completed 07.06.2021 Date Revised 07.06.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/tid.13304 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM309511836 |
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| 245 | 1 | 0 | |a Progressive multifocal leukoencephalopathy presenting with acute sensorineural hearing loss in an intestinal transplant recipient |
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| 520 | |a © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. | ||
| 520 | |a A 20-year-old male presented 3.5 years after intestinal transplantation with rapidly progressive sensorineural hearing loss. Initial brain imaging was consistent with inflammation and/or demyelination. Lumbar puncture was initially non-diagnostic and a broad infectious workup was unrevealing. Three months after presentation, a repeat LP detected JC virus for which tests had not earlier been conducted. He continued to deteriorate despite withdrawal of prior immunosuppression and addition of mirtazapine, maraviroc, and steroids. He died of progressive neurologic decompensation 5 months after his initial presentation. This case highlights progressive multifocal leukoencephalopathy (PML) as a rare complication after solid organ transplantation and acute sensorineural hearing loss as an unusual first presenting symptom of PML. JC virus should be considered in the differential diagnosis of acute sensorineural hearing loss in any immunocompromised patient | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a immune reconstitution inflammatory syndrome | |
| 650 | 4 | |a progressive multifocal leukoencephalopathy | |
| 650 | 4 | |a sensorineural hearing loss | |
| 650 | 4 | |a solid organ transplant | |
| 650 | 4 | |a treatment | |
| 700 | 1 | |a Ocwieja, Karen E |e verfasserin |4 aut | |
| 700 | 1 | |a Iglesias, Julie |e verfasserin |4 aut | |
| 700 | 1 | |a Fawaz, Rima |e verfasserin |4 aut | |
| 700 | 1 | |a Elisofon, Scott |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Christine |e verfasserin |4 aut | |
| 700 | 1 | |a Sharma, Tanvi S |e verfasserin |4 aut | |
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