Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents : a position paper of the ESC Working Group on Myocardial Function

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissionsoup.com..

Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity and progression, testing of new drugs, and monitoring cardiac function in genetically modified or pharmacologically treated animals. However, as yet, there is no standardization in the procedure to acquire echocardiographic measurements in small animals. This position paper focuses on the appropriate acquisition and analysis of echocardiographic parameters in adult mice and rats, and provides reference values, representative images, and videos for the accurate and reproducible quantification of left ventricular function in healthy and pathological conditions.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:117

Enthalten in:

Cardiovascular research - 117(2021), 1 vom: 01. Jan., Seite 43-59

Sprache:

Englisch

Beteiligte Personen:

Zacchigna, Serena [VerfasserIn]
Paldino, Alessia [VerfasserIn]
Falcão-Pires, Inês [VerfasserIn]
Daskalopoulos, Evangelos P [VerfasserIn]
Dal Ferro, Matteo [VerfasserIn]
Vodret, Simone [VerfasserIn]
Lesizza, Pierluigi [VerfasserIn]
Cannatà, Antonio [VerfasserIn]
Miranda-Silva, Daniela [VerfasserIn]
Lourenço, André P [VerfasserIn]
Pinamonti, Bruno [VerfasserIn]
Sinagra, Gianfranco [VerfasserIn]
Weinberger, Florian [VerfasserIn]
Eschenhagen, Thomas [VerfasserIn]
Carrier, Lucie [VerfasserIn]
Kehat, Izhak [VerfasserIn]
Tocchetti, Carlo G [VerfasserIn]
Russo, Michele [VerfasserIn]
Ghigo, Alessandra [VerfasserIn]
Cimino, James [VerfasserIn]
Hirsch, Emilio [VerfasserIn]
Dawson, Dana [VerfasserIn]
Ciccarelli, Michele [VerfasserIn]
Oliveti, Marco [VerfasserIn]
Linke, Wolfgang A [VerfasserIn]
Cuijpers, Ilona [VerfasserIn]
Heymans, Stephane [VerfasserIn]
Hamdani, Nazha [VerfasserIn]
de Boer, Martine [VerfasserIn]
Duncker, Dirk J [VerfasserIn]
Kuster, Diederik [VerfasserIn]
van der Velden, Jolanda [VerfasserIn]
Beauloye, Christophe [VerfasserIn]
Bertrand, Luc [VerfasserIn]
Mayr, Manuel [VerfasserIn]
Giacca, Mauro [VerfasserIn]
Leuschner, Florian [VerfasserIn]
Backs, Johannes [VerfasserIn]
Thum, Thomas [VerfasserIn]

Links:

Volltext

Themen:

Animal models
Diastolic function
Echocardiography
Journal Article
Research Support, Non-U.S. Gov't
Review
Standardization
Systolic function
Video-Audio Media

Anmerkungen:

Date Completed 06.10.2021

Date Revised 23.03.2022

published: Print

Citation Status MEDLINE

doi:

10.1093/cvr/cvaa110

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM309487641