Extramedullary Hematopoiesis in the Sinonasal Cavity : A Case Report and Review of the Literature
© The Author(s) 2020..
BACKGROUND: Extramedullary hematopoiesis (EMH) occurs in patients with hematologic disorders, but rarely within the paranasal sinuses. We report a case of EMH in a 17-year-old male with sickle cell disease (SCD) who presented with occipital pain and sinusitis. A computed tomography (CT) scan demonstrated heterogeneous opacification of the right maxillary sinus concerning for allergic fungal sinusitis or a fungal ball with bony erosion. He was taken to the operating room for endoscopic biopsy and a limited endoscopic sinus surgery. Grossly, his maxillary sinus was filled with spiculated osseous tissue. Final pathology demonstrated active hematopoietic bone marrow filling the sinus.
METHODS: We present a case report and literature review of sinonasal EMH.
RESULTS: We identified 14 articles with 15 patients. EMH was typically associated with SCD or beta thalassemia. The average age of presentation was 30. There was a male sex predilection with a ratio of 11:15. The most common presenting symptom was a headache and nasal obstruction (33% for both). The most common finding on CT was a soft tissue expansile mass (73%). The most commonly affected location was the maxillary sinus (60%).
CONCLUSIONS: This case report serves as a reminder to consider EMH as an uncommon cause of sinus opacification, particularly in patients with SCD or beta thalassemia. The expansion of hematopoietic tissue may be identified as a sinus mass on CT. By recognizing the potential manifestations of chronic anemia, an accurate and timely diagnosis can be made.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Allergy & rhinology (Providence, R.I.) - 11(2020) vom: 15. Jan., Seite 2152656720918874 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Clark, Carly A [VerfasserIn] |
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| Links: |
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| Themen: |
Case Reports |
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| Anmerkungen: |
Date Revised 14.04.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1177/2152656720918874 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM309466571 |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © The Author(s) 2020. | ||
| 520 | |a BACKGROUND: Extramedullary hematopoiesis (EMH) occurs in patients with hematologic disorders, but rarely within the paranasal sinuses. We report a case of EMH in a 17-year-old male with sickle cell disease (SCD) who presented with occipital pain and sinusitis. A computed tomography (CT) scan demonstrated heterogeneous opacification of the right maxillary sinus concerning for allergic fungal sinusitis or a fungal ball with bony erosion. He was taken to the operating room for endoscopic biopsy and a limited endoscopic sinus surgery. Grossly, his maxillary sinus was filled with spiculated osseous tissue. Final pathology demonstrated active hematopoietic bone marrow filling the sinus | ||
| 520 | |a METHODS: We present a case report and literature review of sinonasal EMH | ||
| 520 | |a RESULTS: We identified 14 articles with 15 patients. EMH was typically associated with SCD or beta thalassemia. The average age of presentation was 30. There was a male sex predilection with a ratio of 11:15. The most common presenting symptom was a headache and nasal obstruction (33% for both). The most common finding on CT was a soft tissue expansile mass (73%). The most commonly affected location was the maxillary sinus (60%) | ||
| 520 | |a CONCLUSIONS: This case report serves as a reminder to consider EMH as an uncommon cause of sinus opacification, particularly in patients with SCD or beta thalassemia. The expansion of hematopoietic tissue may be identified as a sinus mass on CT. By recognizing the potential manifestations of chronic anemia, an accurate and timely diagnosis can be made | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a extramedullary hematopoiesis | |
| 650 | 4 | |a paranasal sinus | |
| 650 | 4 | |a sickle cell anemia | |
| 650 | 4 | |a sinonasal mass | |
| 650 | 4 | |a sinus tumor | |
| 700 | 1 | |a Worden, Cameron P |e verfasserin |4 aut | |
| 700 | 1 | |a Thorp, Brian D |e verfasserin |4 aut | |
| 700 | 1 | |a Ebert, Charles S |e verfasserin |4 aut | |
| 700 | 1 | |a Zanation, Adam M |e verfasserin |4 aut | |
| 700 | 1 | |a Senior, Brent A |e verfasserin |4 aut | |
| 700 | 1 | |a M Johnson, Steven |e verfasserin |4 aut | |
| 700 | 1 | |a McClain, Wade G |e verfasserin |4 aut | |
| 700 | 1 | |a Kimple, Adam J |e verfasserin |4 aut | |
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