Solubility of codeine phosphate in carbitol + 2-propanol mixture at different temperatures

The solubility profile of codeine phosphate in the carbitol and 2-propanol mixtures at 293.2-313.2 K are determined and correlated with some developed cosolvency models. Moreover, the density values of codeine phosphate saturated solutions are also determined and fitted with the Jouyban-Acree model. The model accuracy is investigated by calculating the mean relative deviations (MRDs%). The thermodynamic parameters of codeine phosphate dissolution in the non-aqueous mixtures of carbitol and 2-propanol are also computed by using van't Hoff and Gibbs equations.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:46

Enthalten in:

Drug development and industrial pharmacy - 46(2020), 6 vom: 01. Juni, Seite 910-915

Sprache:

Englisch

Beteiligte Personen:

Rezaei, Homa [VerfasserIn]
Jouyban, Abolghasem [VerfasserIn]
Martinez, Fleming [VerfasserIn]
Barzegar-Jalali, Mohammad [VerfasserIn]
Rahimpour, Elaheh [VerfasserIn]

Links:

Volltext

Themen:

1-Propanol
2-Propanol
2-propanol
96F264O9SV
A1A1I8X02B
Carbitol
Codeine
Codeine phosphate
Cosolvency models
Ethylene Glycols
Journal Article
ND2M416302
Solubility
Solvent mixtures
Solvents
UX6OWY2V7J

Anmerkungen:

Date Completed 03.03.2021

Date Revised 03.03.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1080/03639045.2020.1762203

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM309230721