Conjunctivitis, the key clinical characteristic of adult rubella in Japan during two large outbreaks, 2012-2013 and 2018-2019
BACKGROUND: Rubella virus infection mainly causes illness with mild fever, rash, and lymphadenopathy in children; however, the clinical characteristics of adult rubella are not well-known.
METHODS: An observational study was conducted to compare the characteristics between adult rubella and adult non-rubella among participants aged ≥18 years, with suspected symptomatic rubella. Participants were screened for rubella-specific IgM expression using an enzyme immune assay kit, at a tertiary care hospital in Japan during two outbreaks (January 2012-December 2013 and January 2018-March 2019). Adult rubella diagnosis followed strong positive or paired rubella-specific IgM expression or positive rubella-specific reverse-transcription-polymerase chain reaction. Patients aged <18 years or with clinically suspected rubella with weak or negative IgM expression were excluded.
RESULTS: Overall, 82 adult rubella and 139 adult non-rubella, with a median age (interquartile range) of 31 (25-41) years and 34 (27-42) years, respectively, were included. Multivariate analysis showed that conjunctivitis (odds ratio 80.6; 95% confidence interval 13.4-486.3; P <0.001) and male sex (odds ratio 7.1; 95% confidence interval 1.8-28.1; P = 0.005) were significantly associated with adult rubella. Among men born from 1962 to 1979 (high-risk population, n = 68), conjunctivitis also showed a significant association with adult rubella in the multivariate analysis (odds ratio 24.2; 95% confidence interval 1.1-553.7; P = 0.046) as these patients were not included in the national vaccination program. There was no difference in the clinical characteristics between one-time vaccination (n = 11) and no vaccination (n = 8) patient in the adult rubella group.
CONCLUSIONS: Conjunctivitis was the key clinical symptom associated with adult rubella. For the early diagnosis of adult rubella, clinicians should focus on assessing conjunctivitis in patients.
| Errataetall: |
ErratumIn: PLoS One. 2022 Aug 4;17(8):e0272880. - PMID 35926000 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
PloS one - 15(2020), 4 vom: 24., Seite e0231966 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nomoto, Hidetoshi [VerfasserIn] |
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| Anmerkungen: |
Date Completed 20.07.2020 Date Revised 04.08.2022 published: Electronic-eCollection ErratumIn: PLoS One. 2022 Aug 4;17(8):e0272880. - PMID 35926000 Citation Status MEDLINE |
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| doi: |
10.1371/journal.pone.0231966 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM309144833 |
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| 245 | 1 | 0 | |a Conjunctivitis, the key clinical characteristic of adult rubella in Japan during two large outbreaks, 2012-2013 and 2018-2019 |
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| 500 | |a ErratumIn: PLoS One. 2022 Aug 4;17(8):e0272880. - PMID 35926000 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Rubella virus infection mainly causes illness with mild fever, rash, and lymphadenopathy in children; however, the clinical characteristics of adult rubella are not well-known | ||
| 520 | |a METHODS: An observational study was conducted to compare the characteristics between adult rubella and adult non-rubella among participants aged ≥18 years, with suspected symptomatic rubella. Participants were screened for rubella-specific IgM expression using an enzyme immune assay kit, at a tertiary care hospital in Japan during two outbreaks (January 2012-December 2013 and January 2018-March 2019). Adult rubella diagnosis followed strong positive or paired rubella-specific IgM expression or positive rubella-specific reverse-transcription-polymerase chain reaction. Patients aged <18 years or with clinically suspected rubella with weak or negative IgM expression were excluded | ||
| 520 | |a RESULTS: Overall, 82 adult rubella and 139 adult non-rubella, with a median age (interquartile range) of 31 (25-41) years and 34 (27-42) years, respectively, were included. Multivariate analysis showed that conjunctivitis (odds ratio 80.6; 95% confidence interval 13.4-486.3; P <0.001) and male sex (odds ratio 7.1; 95% confidence interval 1.8-28.1; P = 0.005) were significantly associated with adult rubella. Among men born from 1962 to 1979 (high-risk population, n = 68), conjunctivitis also showed a significant association with adult rubella in the multivariate analysis (odds ratio 24.2; 95% confidence interval 1.1-553.7; P = 0.046) as these patients were not included in the national vaccination program. There was no difference in the clinical characteristics between one-time vaccination (n = 11) and no vaccination (n = 8) patient in the adult rubella group | ||
| 520 | |a CONCLUSIONS: Conjunctivitis was the key clinical symptom associated with adult rubella. For the early diagnosis of adult rubella, clinicians should focus on assessing conjunctivitis in patients | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Ishikane, Masahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamoto, Takato |e verfasserin |4 aut | |
| 700 | 1 | |a Ohta, Masayuki |e verfasserin |4 aut | |
| 700 | 1 | |a Morioka, Shinichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Yamamoto, Kei |e verfasserin |4 aut | |
| 700 | 1 | |a Kutsuna, Satoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Tezuka, Shunsuke |e verfasserin |4 aut | |
| 700 | 1 | |a Kunimatsu, Junwa |e verfasserin |4 aut | |
| 700 | 1 | |a Ohmagari, Norio |e verfasserin |4 aut | |
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