Lifestyle factors and long-term survival of gastric cancer patients : A large bidirectional cohort study from China
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved..
BACKGROUND: Lifestyle factors such as body mass index (BMI), alcohol drinking, and cigarette smoking, are likely to impact the prognosis of gastric cancer, but the evidence has been inconsistent.
AIM: To investigate the association of lifestyle factors and long-term prognosis of gastric cancer patients in the China National Cancer Center.
METHODS: Patients with gastric cancer were identified from the China National Cancer Center Gastric Cancer Database 1998-2018. Survival analysis was performed via Kaplan-Meier estimates and Cox proportional hazards models.
RESULTS: In this study, we reviewed 18441 cases of gastric cancer. Individuals who were overweight or obese were associated with a positive smoking and drinking history (P = 0.002 and P < 0.001, respectively). Current smokers were more likely to be current alcohol drinkers (61.3% vs 10.1% vs 43.2% for current, never, and former smokers, respectively, P < 0.001). Multivariable results indicated that BMI at diagnosis had no significant effect on prognosis. In gastrectomy patients, factors independently associated with poor survival included older age (HR = 1.20, 95%CI: 1.05-1.38, P = 0.001), any weight loss (P < 0.001), smoking history of more than 30 years (HR = 1.14, 95%CI: 1.04-1.24, P = 0.004), and increasing pTNM stage (P < 0.001).
CONCLUSION: In conclusion, our results contribute to a better understanding of lifestyle factors on the overall burden of gastric cancer and long-term prognosis. In these patients, weight loss (both in the 0 to 10% and > 10% groups) but not BMI at diagnosis was related to survival outcomes. With regard to other factors, smoking history of more than 30 years conferred a worse prognosis only in patients who underwent gastrectomy. Extensive efforts are needed to elucidate mechanisms targeting the complex effects of lifestyle factors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
World journal of gastroenterology - 26(2020), 14 vom: 14. Apr., Seite 1613-1627 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhao, Lu-Lu [VerfasserIn] |
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| Links: |
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| Themen: |
Body mass index |
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| Anmerkungen: |
Date Completed 08.02.2021 Date Revised 08.02.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.3748/wjg.v26.i14.1613 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM309122538 |
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| 100 | 1 | |a Zhao, Lu-Lu |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Lifestyle factors and long-term survival of gastric cancer patients |b A large bidirectional cohort study from China |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Lifestyle factors such as body mass index (BMI), alcohol drinking, and cigarette smoking, are likely to impact the prognosis of gastric cancer, but the evidence has been inconsistent | ||
| 520 | |a AIM: To investigate the association of lifestyle factors and long-term prognosis of gastric cancer patients in the China National Cancer Center | ||
| 520 | |a METHODS: Patients with gastric cancer were identified from the China National Cancer Center Gastric Cancer Database 1998-2018. Survival analysis was performed via Kaplan-Meier estimates and Cox proportional hazards models | ||
| 520 | |a RESULTS: In this study, we reviewed 18441 cases of gastric cancer. Individuals who were overweight or obese were associated with a positive smoking and drinking history (P = 0.002 and P < 0.001, respectively). Current smokers were more likely to be current alcohol drinkers (61.3% vs 10.1% vs 43.2% for current, never, and former smokers, respectively, P < 0.001). Multivariable results indicated that BMI at diagnosis had no significant effect on prognosis. In gastrectomy patients, factors independently associated with poor survival included older age (HR = 1.20, 95%CI: 1.05-1.38, P = 0.001), any weight loss (P < 0.001), smoking history of more than 30 years (HR = 1.14, 95%CI: 1.04-1.24, P = 0.004), and increasing pTNM stage (P < 0.001) | ||
| 520 | |a CONCLUSION: In conclusion, our results contribute to a better understanding of lifestyle factors on the overall burden of gastric cancer and long-term prognosis. In these patients, weight loss (both in the 0 to 10% and > 10% groups) but not BMI at diagnosis was related to survival outcomes. With regard to other factors, smoking history of more than 30 years conferred a worse prognosis only in patients who underwent gastrectomy. Extensive efforts are needed to elucidate mechanisms targeting the complex effects of lifestyle factors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Body mass index | |
| 650 | 4 | |a Cigarette smoking | |
| 650 | 4 | |a Cohort study | |
| 650 | 4 | |a Gastric cancer | |
| 650 | 4 | |a Lifestyle factors | |
| 650 | 4 | |a Prognosis | |
| 700 | 1 | |a Huang, Huang |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yang |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Tong-Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Fu-Hai |e verfasserin |4 aut | |
| 700 | 1 | |a Ren, Hu |e verfasserin |4 aut | |
| 700 | 1 | |a Niu, Peng-Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Dong-Bing |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Ying-Tai |e verfasserin |4 aut | |
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