Perinatal selective serotonin reuptake inhibitor exposure and behavioral outcomes : A systematic review and meta-analyses of animal studies
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved..
In the Western world, 2-5 % of pregnant women use selective serotonin reuptake inhibitor (SSRI) antidepressants. There is no consensus on the potential long-term neurodevelopmental outcomes of early SSRI exposure. Our aim was to determine whether there is an overall effect of perinatal SSRI exposure in animals on a spectrum of behavioral domains. After a comprehensive database search in PubMed, PsycINFO, and Web of Science, we included 99 publications. We performed nine meta-analyses and two qualitative syntheses corresponding to different behavioral categories, aggregating data from thousands of animals. We found evidence for reduced activity and exploration behavior (standardized mean difference (SMD) -0.28 [-0.38, -0.18]), more passive stress coping (SMD -0.37 [-0.52, -0.23]), and less efficient sensory processing (SMD -0.37 [-0.69, -0.06]) in SSRI- versus vehicle-exposed animals. No differences were found for anxiety (p = 0.06), social behavior, learning and memory, ingestive- and reward behavior, motoric behavior, or reflex and pain sensitivity. Exposure in the period equivalent to the human third trimester was associated with the strongest effects.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:114 |
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| Enthalten in: |
Neuroscience and biobehavioral reviews - 114(2020) vom: 01. Juli, Seite 53-69 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ramsteijn, A S [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 21.06.2021 Date Revised 07.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.neubiorev.2020.04.010 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM309052157 |
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| 520 | |a Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a In the Western world, 2-5 % of pregnant women use selective serotonin reuptake inhibitor (SSRI) antidepressants. There is no consensus on the potential long-term neurodevelopmental outcomes of early SSRI exposure. Our aim was to determine whether there is an overall effect of perinatal SSRI exposure in animals on a spectrum of behavioral domains. After a comprehensive database search in PubMed, PsycINFO, and Web of Science, we included 99 publications. We performed nine meta-analyses and two qualitative syntheses corresponding to different behavioral categories, aggregating data from thousands of animals. We found evidence for reduced activity and exploration behavior (standardized mean difference (SMD) -0.28 [-0.38, -0.18]), more passive stress coping (SMD -0.37 [-0.52, -0.23]), and less efficient sensory processing (SMD -0.37 [-0.69, -0.06]) in SSRI- versus vehicle-exposed animals. No differences were found for anxiety (p = 0.06), social behavior, learning and memory, ingestive- and reward behavior, motoric behavior, or reflex and pain sensitivity. Exposure in the period equivalent to the human third trimester was associated with the strongest effects | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a Activity and exploration | |
| 650 | 4 | |a Animal studies | |
| 650 | 4 | |a Antidepressants | |
| 650 | 4 | |a Anxiety | |
| 650 | 4 | |a Behavior | |
| 650 | 4 | |a Developmental exposure | |
| 650 | 4 | |a Ingestive and reward behavior | |
| 650 | 4 | |a Learning and memory | |
| 650 | 4 | |a Meta-analysis | |
| 650 | 4 | |a Motoric behavior | |
| 650 | 4 | |a Offspring | |
| 650 | 4 | |a Pregnancy | |
| 650 | 4 | |a Reflex and pain sensitivity | |
| 650 | 4 | |a Selective serotonin reuptake inhibitors (SSRIs) | |
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| 650 | 4 | |a Sleep and circadian activity | |
| 650 | 4 | |a Social behavior | |
| 650 | 4 | |a Stress coping | |
| 650 | 4 | |a Systematic review | |
| 650 | 4 | |a Teratogenic effects | |
| 650 | 7 | |a Antidepressive Agents |2 NLM | |
| 650 | 7 | |a Serotonin Uptake Inhibitors |2 NLM | |
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| 700 | 1 | |a van Luijk, J |e verfasserin |4 aut | |
| 700 | 1 | |a Homberg, J R |e verfasserin |4 aut | |
| 700 | 1 | |a Olivier, J D A |e verfasserin |4 aut | |
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