Depletion of langerin+ cells enhances cutaneous wound healing
© 2020 John Wiley & Sons Ltd..
Langerin is a C-type lectin receptor that is expressed on Langerhans cells and langerin-positive dermal dendritic cells in the skin. Little is known about the function of langerin+ cells in wound healing. In this study, the effects of ablation of langerin+ cells on healing of a full-thickness excision wound were investigated using the langerin-DTR depletable mouse. Strikingly, depletion of langerin+ cells resulted in more rapid reduction in wound area. Accelerated wound healing in the langerin+ -cell-depleted group was characterized by enhanced neo-epidermis and granulation tissue formation, and increased cellular proliferation within the newly formed tissues. Accelerated healing in the absence of langerin+ cells was associated with increased levels of granulocyte-macrophage colony-stimulating factor, F4/80+ cells and blood vessels within the granulation tissue. These data support an inhibitory role for langerin+ cells during wound healing. Therapies that suppress langerin+ cells or their function may therefore have utility in progressing the healing of wounds in humans.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2020 |
---|---|
Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:160 |
---|---|
Enthalten in: |
Immunology - 160(2020), 4 vom: 19. Aug., Seite 366-381 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Rajesh, Aarthi [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 26.05.2021 Date Revised 02.08.2021 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1111/imm.13202 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM308924703 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM308924703 | ||
003 | DE-627 | ||
005 | 20231225132804.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2020 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1111/imm.13202 |2 doi | |
028 | 5 | 2 | |a pubmed24n1029.xml |
035 | |a (DE-627)NLM308924703 | ||
035 | |a (NLM)32307696 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Rajesh, Aarthi |e verfasserin |4 aut | |
245 | 1 | 0 | |a Depletion of langerin+ cells enhances cutaneous wound healing |
264 | 1 | |c 2020 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 26.05.2021 | ||
500 | |a Date Revised 02.08.2021 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2020 John Wiley & Sons Ltd. | ||
520 | |a Langerin is a C-type lectin receptor that is expressed on Langerhans cells and langerin-positive dermal dendritic cells in the skin. Little is known about the function of langerin+ cells in wound healing. In this study, the effects of ablation of langerin+ cells on healing of a full-thickness excision wound were investigated using the langerin-DTR depletable mouse. Strikingly, depletion of langerin+ cells resulted in more rapid reduction in wound area. Accelerated wound healing in the langerin+ -cell-depleted group was characterized by enhanced neo-epidermis and granulation tissue formation, and increased cellular proliferation within the newly formed tissues. Accelerated healing in the absence of langerin+ cells was associated with increased levels of granulocyte-macrophage colony-stimulating factor, F4/80+ cells and blood vessels within the granulation tissue. These data support an inhibitory role for langerin+ cells during wound healing. Therapies that suppress langerin+ cells or their function may therefore have utility in progressing the healing of wounds in humans | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Langerhans cells | |
650 | 4 | |a angiogenesis | |
650 | 4 | |a epithelialization | |
650 | 4 | |a langerin-positive dermal dendritic cells | |
650 | 4 | |a mouse | |
650 | 4 | |a skin | |
650 | 4 | |a wound healing | |
650 | 7 | |a Angiogenesis Inducing Agents |2 NLM | |
650 | 7 | |a Antigens, Surface |2 NLM | |
650 | 7 | |a Cd207 protein, mouse |2 NLM | |
650 | 7 | |a Lectins, C-Type |2 NLM | |
650 | 7 | |a Mannose-Binding Lectins |2 NLM | |
650 | 7 | |a Granulocyte-Macrophage Colony-Stimulating Factor |2 NLM | |
650 | 7 | |a 83869-56-1 |2 NLM | |
700 | 1 | |a Stuart, Gabriella |e verfasserin |4 aut | |
700 | 1 | |a Real, Nicola |e verfasserin |4 aut | |
700 | 1 | |a Ahn, Jenny |e verfasserin |4 aut | |
700 | 1 | |a Tschirley, Allison |e verfasserin |4 aut | |
700 | 1 | |a Wise, Lyn |e verfasserin |4 aut | |
700 | 1 | |a Hibma, Merilyn |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Immunology |d 1958 |g 160(2020), 4 vom: 19. Aug., Seite 366-381 |w (DE-627)NLM000004219 |x 1365-2567 |7 nnns |
773 | 1 | 8 | |g volume:160 |g year:2020 |g number:4 |g day:19 |g month:08 |g pages:366-381 |
856 | 4 | 0 | |u http://dx.doi.org/10.1111/imm.13202 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 160 |j 2020 |e 4 |b 19 |c 08 |h 366-381 |