Extracellular vesicle-mediated nucleic acid transfer and reprogramming in the tumor microenvironment
Copyright © 2020 Elsevier B.V. All rights reserved..
Extracellular vesicles (EVs) have garnered much attention as key mediators of intercellular communication within the tumor microenvironment (TME) as well as at distinct metastatic sites. Nucleic acid molecules are the important components of the EV cargo. Characterizing EVs and strategies for modulating the nucleic acid content to promote anti-tumoral functions has led to the emerging role of EVs as potential novel targets for cancer therapy. Recent approaches of engineering the EVs to reach targeted sites have bought this to the forefront for nucleic acid delivery. In this article, we discuss EV biology with recent methods to analyze their nucleic acid contents. We emphasize the role of EV-mediated nucleic acid transfer in the TME assisting in tumor progression and metastasis and further review the strategies for modulating the nucleic acid content in EV for suppressing tumor growth and immune activation. The article further discusses the recent developments in generating EV mimics as nucleic acid delivery systems.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:482 |
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| Enthalten in: |
Cancer letters - 482(2020) vom: 10. Juli, Seite 33-43 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Parayath, Neha N [VerfasserIn] |
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| Links: |
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| Themen: |
Biogenesis |
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| Anmerkungen: |
Date Completed 05.01.2021 Date Revised 05.01.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.canlet.2020.04.009 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM30874439X |
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| 500 | |a Date Revised 05.01.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier B.V. All rights reserved. | ||
| 520 | |a Extracellular vesicles (EVs) have garnered much attention as key mediators of intercellular communication within the tumor microenvironment (TME) as well as at distinct metastatic sites. Nucleic acid molecules are the important components of the EV cargo. Characterizing EVs and strategies for modulating the nucleic acid content to promote anti-tumoral functions has led to the emerging role of EVs as potential novel targets for cancer therapy. Recent approaches of engineering the EVs to reach targeted sites have bought this to the forefront for nucleic acid delivery. In this article, we discuss EV biology with recent methods to analyze their nucleic acid contents. We emphasize the role of EV-mediated nucleic acid transfer in the TME assisting in tumor progression and metastasis and further review the strategies for modulating the nucleic acid content in EV for suppressing tumor growth and immune activation. The article further discusses the recent developments in generating EV mimics as nucleic acid delivery systems | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Biogenesis | |
| 650 | 4 | |a EV-Mimics | |
| 650 | 4 | |a Exosomes | |
| 650 | 4 | |a Extracellular vesicles | |
| 650 | 4 | |a Reprogramming | |
| 650 | 4 | |a Tumor microenvironment | |
| 650 | 7 | |a Nucleic Acids |2 NLM | |
| 700 | 1 | |a Padmakumar, Smrithi |e verfasserin |4 aut | |
| 700 | 1 | |a Amiji, Mansoor M |e verfasserin |4 aut | |
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