Relevance of humanized three-dimensional tumor tissue models : a descriptive systematic literature review
Despite numerous advances in tumor screening, diagnosis, and treatment, to date, tumors remain one of the leading causes of death, principally due to metastasis and the physiological damage produced by tumor growth. Among the main limits related to the study of tumor physiology there is the complex and heterogeneity nature of its environment and the absence of relevant, simple and inexpensive models able to mimic the biological processes occurring in patients allowing the correct clinical translation of results. To enhance the understanding of the mechanisms of tumors and to develop and evaluate new therapeutic approaches the set-up of advanced and alternative models is mandatory. One of the more translational approaches seems to be the use of humanized three-dimensional (3D) tissue culture. This model allows to accurately mimic tumor morphology and biology, maintaining the native microenvironment without any manipulation. However, little is still known on the real clinical relevance of these models for the study of tumor mechanisms and for the screening of new therapy. The aim of this descriptive systematic literature review was to evaluate and summarize the current knowledge on human 3D tumor tissue culture models. We reviewed the strategies employed by researchers to set-up these systems, also considering the different approaches and culture conditions used. All these aspects greatly contribute to the existing knowledge on tumors, providing a specific link to clinical scenarios and making the humanized 3D tumor tissue models a more attractive tool both for researchers and clinicians.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2020 |
---|---|
Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:77 |
---|---|
Enthalten in: |
Cellular and molecular life sciences : CMLS - 77(2020), 20 vom: 29. Okt., Seite 3913-3944 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Contartese, D [VerfasserIn] |
---|
Links: |
---|
Themen: |
Clinical translation |
---|
Anmerkungen: |
Date Completed 13.10.2020 Date Revised 02.02.2021 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1007/s00018-020-03513-y |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM308701526 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM308701526 | ||
003 | DE-627 | ||
005 | 20231225132308.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2020 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s00018-020-03513-y |2 doi | |
028 | 5 | 2 | |a pubmed24n1028.xml |
035 | |a (DE-627)NLM308701526 | ||
035 | |a (NLM)32285137 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Contartese, D |e verfasserin |4 aut | |
245 | 1 | 0 | |a Relevance of humanized three-dimensional tumor tissue models |b a descriptive systematic literature review |
264 | 1 | |c 2020 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 13.10.2020 | ||
500 | |a Date Revised 02.02.2021 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Despite numerous advances in tumor screening, diagnosis, and treatment, to date, tumors remain one of the leading causes of death, principally due to metastasis and the physiological damage produced by tumor growth. Among the main limits related to the study of tumor physiology there is the complex and heterogeneity nature of its environment and the absence of relevant, simple and inexpensive models able to mimic the biological processes occurring in patients allowing the correct clinical translation of results. To enhance the understanding of the mechanisms of tumors and to develop and evaluate new therapeutic approaches the set-up of advanced and alternative models is mandatory. One of the more translational approaches seems to be the use of humanized three-dimensional (3D) tissue culture. This model allows to accurately mimic tumor morphology and biology, maintaining the native microenvironment without any manipulation. However, little is still known on the real clinical relevance of these models for the study of tumor mechanisms and for the screening of new therapy. The aim of this descriptive systematic literature review was to evaluate and summarize the current knowledge on human 3D tumor tissue culture models. We reviewed the strategies employed by researchers to set-up these systems, also considering the different approaches and culture conditions used. All these aspects greatly contribute to the existing knowledge on tumors, providing a specific link to clinical scenarios and making the humanized 3D tumor tissue models a more attractive tool both for researchers and clinicians | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Systematic Review | |
650 | 4 | |a Clinical translation | |
650 | 4 | |a Metastasis | |
650 | 4 | |a Systematic literature review | |
650 | 4 | |a Three-dimensional model | |
650 | 4 | |a Tissue culture | |
650 | 4 | |a Tumor | |
700 | 1 | |a Salamanna, Francesca |e verfasserin |4 aut | |
700 | 1 | |a Veronesi, F |e verfasserin |4 aut | |
700 | 1 | |a Fini, M |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Cellular and molecular life sciences : CMLS |d 1997 |g 77(2020), 20 vom: 29. Okt., Seite 3913-3944 |w (DE-627)NLM090610393 |x 1420-9071 |7 nnns |
773 | 1 | 8 | |g volume:77 |g year:2020 |g number:20 |g day:29 |g month:10 |g pages:3913-3944 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00018-020-03513-y |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 77 |j 2020 |e 20 |b 29 |c 10 |h 3913-3944 |