Evaluating ternary systems with oligosaccharides as a strategy to improve the biopharmaceutical properties of furosemide
Copyright © 2020 Elsevier B.V. All rights reserved..
Novel ternary systems with β-cyclodextrin or maltodextrin and triethanolamine as the third component were developed with the aim of improving the oral bioavailability of furosemide. These new solids were characterized by solid-state nuclear magnetic resonance, Fourier transform infrared and Raman spectroscopy, X-ray powder diffractometry, scanning electron microscopy, thermogravimetric analysis, and differential scanning calorimetry. The solubility, dissolution and stability (chemical and physical) were studied. Among the most important results, it was observed that both ternary systems showed an important enhancement in the solubility of the drug. In particular, the system obtained by combination of β-cyclodextrin and TEA exhibited improvement in the dissolution profiles and photo-stability of furosemide compared with the binary system previously reported. Moreover, this system constitutes an interesting therapeutic alternative as it did not produce cellular toxicity compared with free furosemide. In conclusion, the results obtained revealed that this ternary system establishes a promising approach for oral delivery of the drug.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:111 |
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| Enthalten in: |
Materials science & engineering. C, Materials for biological applications - 111(2020) vom: 15. Juni, Seite 110793 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Abraham-Miranda, Julieta [VerfasserIn] |
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| Links: |
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| Themen: |
7LXU5N7ZO5 |
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| Anmerkungen: |
Date Completed 07.01.2021 Date Revised 07.01.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.msec.2020.110793 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM308649052 |
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| 520 | |a Copyright © 2020 Elsevier B.V. All rights reserved. | ||
| 520 | |a Novel ternary systems with β-cyclodextrin or maltodextrin and triethanolamine as the third component were developed with the aim of improving the oral bioavailability of furosemide. These new solids were characterized by solid-state nuclear magnetic resonance, Fourier transform infrared and Raman spectroscopy, X-ray powder diffractometry, scanning electron microscopy, thermogravimetric analysis, and differential scanning calorimetry. The solubility, dissolution and stability (chemical and physical) were studied. Among the most important results, it was observed that both ternary systems showed an important enhancement in the solubility of the drug. In particular, the system obtained by combination of β-cyclodextrin and TEA exhibited improvement in the dissolution profiles and photo-stability of furosemide compared with the binary system previously reported. Moreover, this system constitutes an interesting therapeutic alternative as it did not produce cellular toxicity compared with free furosemide. In conclusion, the results obtained revealed that this ternary system establishes a promising approach for oral delivery of the drug | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cellular toxicity | |
| 650 | 4 | |a Dissolution | |
| 650 | 4 | |a Furosemide | |
| 650 | 4 | |a Oligosaccharides | |
| 650 | 4 | |a Stability | |
| 650 | 4 | |a Triethanolamine | |
| 650 | 7 | |a Biological Products |2 NLM | |
| 650 | 7 | |a Oligosaccharides |2 NLM | |
| 650 | 7 | |a Powders |2 NLM | |
| 650 | 7 | |a Furosemide |2 NLM | |
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| 700 | 1 | |a Zoppi, Ariana |e verfasserin |4 aut | |
| 700 | 1 | |a Chattah, Ana K |e verfasserin |4 aut | |
| 700 | 1 | |a Sterren, Vanesa B |e verfasserin |4 aut | |
| 700 | 1 | |a Santiago de Oliveira, Yara |e verfasserin |4 aut | |
| 700 | 1 | |a Ayala, Alejandro P |e verfasserin |4 aut | |
| 700 | 1 | |a Longhi, Marcela R |e verfasserin |4 aut | |
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