Antiproliferative activity of caged xanthones from the leaves of Garcinia wightii T. Anderson
Copyright © 2020 Elsevier B.V. All rights reserved..
Two new caged xanthones, wightiic acid (1) 16-O-methyl wightiic acid (2), along with eight known compounds, gaudichaudic acid E (3), isogaudichaudic acid E (4), ursolic acid (5) stigmasterol (6), lupeol (7), glutinol (8), lupenone (9) and stigmasteryl linoleate (10) were isolated from Garcinia wightii T. Anderson. The structures of the compounds were elucidated by spectroscopic means, including 1D and 2D NMR, HR-ESIMS, and the absolute configuration of the new compounds 1 and 2 were determined by analysis of ECD data. Anti-proliferation activities of the four caged xanthones (1-4) were evaluated by MTT assay on MCF-7 and SKBR-3 human breast cancer cells and A-375 human melanoma cells by MTT assay. All the tested compounds exhibited dose dependent antiproliferative activity. Wightiic acid (1) showed remarkable activity with IC50 value of 4.7 μM and 5.2 μM respectively in A-375 and MCF-7 cells. The compound isogaudichaudic acid E (4) induced potent antiproliferation against SKBR-3 cells with an IC50 value of 6.1 μM.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:143 |
|---|---|
| Enthalten in: |
Fitoterapia - 143(2020) vom: 15. Juni, Seite 104592 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Menon, Lekshmi N [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
16-O-methyl wightiic acid |
|---|
| Anmerkungen: |
Date Completed 03.02.2021 Date Revised 03.02.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.fitote.2020.104592 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM30863120X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM30863120X | ||
| 003 | DE-627 | ||
| 005 | 20231225132136.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.fitote.2020.104592 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1028.xml |
| 035 | |a (DE-627)NLM30863120X | ||
| 035 | |a (NLM)32278024 | ||
| 035 | |a (PII)S0367-326X(20)30174-X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Menon, Lekshmi N |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Antiproliferative activity of caged xanthones from the leaves of Garcinia wightii T. Anderson |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 03.02.2021 | ||
| 500 | |a Date Revised 03.02.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier B.V. All rights reserved. | ||
| 520 | |a Two new caged xanthones, wightiic acid (1) 16-O-methyl wightiic acid (2), along with eight known compounds, gaudichaudic acid E (3), isogaudichaudic acid E (4), ursolic acid (5) stigmasterol (6), lupeol (7), glutinol (8), lupenone (9) and stigmasteryl linoleate (10) were isolated from Garcinia wightii T. Anderson. The structures of the compounds were elucidated by spectroscopic means, including 1D and 2D NMR, HR-ESIMS, and the absolute configuration of the new compounds 1 and 2 were determined by analysis of ECD data. Anti-proliferation activities of the four caged xanthones (1-4) were evaluated by MTT assay on MCF-7 and SKBR-3 human breast cancer cells and A-375 human melanoma cells by MTT assay. All the tested compounds exhibited dose dependent antiproliferative activity. Wightiic acid (1) showed remarkable activity with IC50 value of 4.7 μM and 5.2 μM respectively in A-375 and MCF-7 cells. The compound isogaudichaudic acid E (4) induced potent antiproliferation against SKBR-3 cells with an IC50 value of 6.1 μM | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 16-O-methyl wightiic acid | |
| 650 | 4 | |a Antiproliferative activity | |
| 650 | 4 | |a Caged xanthones | |
| 650 | 4 | |a Garcinia wightii | |
| 650 | 4 | |a Wightiic acid | |
| 650 | 7 | |a Antineoplastic Agents, Phytogenic |2 NLM | |
| 650 | 7 | |a Phytochemicals |2 NLM | |
| 650 | 7 | |a Xanthones |2 NLM | |
| 700 | 1 | |a Satheesh, S K Kavya |e verfasserin |4 aut | |
| 700 | 1 | |a Panicker, Sreejith Parameswara |e verfasserin |4 aut | |
| 700 | 1 | |a Rameshkumar, K B |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Fitoterapia |d 1948 |g 143(2020) vom: 15. Juni, Seite 104592 |w (DE-627)NLM106553100 |x 1873-6971 |7 nnns |
| 773 | 1 | 8 | |g volume:143 |g year:2020 |g day:15 |g month:06 |g pages:104592 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.fitote.2020.104592 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 143 |j 2020 |b 15 |c 06 |h 104592 | ||