A long-lifetime iridium(iii) complex for lysosome tracking with high specificity and a large Stokes shift
Investigating the role of lysosome dysfunction in cancer requires the development of efficient probes for lysosomes. We report herein a cyclometalated iridium(iii) complex (Ir-Ly) as a luminescent probe for visualizing lysosomes in cancer cells. The morpholine and hydroxy moieties within Ir-Ly provide suitable hydrophilicity and responsiveness to pH. Importantly, Ir-Ly exhibits a large Stokes shift, long lifetime and high photostability, which are important advantages for lysosome tracking in living cells.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:6 |
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| Enthalten in: |
Journal of materials chemistry. B - 6(2018), 23 vom: 21. Juni, Seite 3855-3858 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Jin-Biao [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 07.04.2020 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/c8tb00666k |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM308396316 |
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| 100 | 1 | |a Liu, Jin-Biao |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A long-lifetime iridium(iii) complex for lysosome tracking with high specificity and a large Stokes shift |
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| 500 | |a Date Revised 07.04.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Investigating the role of lysosome dysfunction in cancer requires the development of efficient probes for lysosomes. We report herein a cyclometalated iridium(iii) complex (Ir-Ly) as a luminescent probe for visualizing lysosomes in cancer cells. The morpholine and hydroxy moieties within Ir-Ly provide suitable hydrophilicity and responsiveness to pH. Importantly, Ir-Ly exhibits a large Stokes shift, long lifetime and high photostability, which are important advantages for lysosome tracking in living cells | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Vellaisamy, Kasipandi |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Guodong |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Chao |e verfasserin |4 aut | |
| 700 | 1 | |a Wong, Suk-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Leung, Chung-Hang |e verfasserin |4 aut | |
| 700 | 1 | |a Pu, Shou-Zhi |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Dik-Lung |e verfasserin |4 aut | |
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