Does Normothermic Regional Perfusion Improve the Results of Donation After Circulatory Death Liver Transplantation?
Copyright © 2020 Elsevier Inc. All rights reserved..
BACKGROUND: The so-called grafts or donors with extended criteria are a risk factor for the development of liver transplant activity. One source comes from controlled donation after circulatory death (cDCD). The hypothesis was to verify the improvement in results by comparing DCD liver transplants performed with postmortem normothermic regional perfusion (NRP) vs super-rapid recovery (SRR), the current standard for cDCD. A prospective study comparing both techniques was carried out.
METHODS: A total of 42 transplants were performed with cDCD, 22 of which were with SRR and 23 with NRP from April 2014 to September 2019.
RESULTS: Differences were found in early allograft dysfunction (68.1% in the SRR group vs 25% in the NRP group; P < .01) and biliary complications (22.7% vs 5%, respectively; P = .04). Differences were also found, although not statistically significant, in ischemic cholangiopathy (13.6% in the SRR group vs 5% in the NRP group; P = .09), and retransplant rate (9.1% vs 0%, respectively; P = .3).
CONCLUSIONS: With the use of NRP machines, results are similar to the standard donation with donors in brain death in terms of rate of early allograft dysfunction and survival of the patient and graft attempted, reducing the rate of ischemic cholangiopathy compared with SRR.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:52 |
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| Enthalten in: |
Transplantation proceedings - 52(2020), 5 vom: 14. Juni, Seite 1477-1480 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Muñoz, Daniel Cabañó [VerfasserIn] |
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| Anmerkungen: |
Date Completed 02.11.2020 Date Revised 02.11.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.transproceed.2020.01.088 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM308383370 |
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| 245 | 1 | 0 | |a Does Normothermic Regional Perfusion Improve the Results of Donation After Circulatory Death Liver Transplantation? |
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| 500 | |a Date Revised 02.11.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: The so-called grafts or donors with extended criteria are a risk factor for the development of liver transplant activity. One source comes from controlled donation after circulatory death (cDCD). The hypothesis was to verify the improvement in results by comparing DCD liver transplants performed with postmortem normothermic regional perfusion (NRP) vs super-rapid recovery (SRR), the current standard for cDCD. A prospective study comparing both techniques was carried out | ||
| 520 | |a METHODS: A total of 42 transplants were performed with cDCD, 22 of which were with SRR and 23 with NRP from April 2014 to September 2019 | ||
| 520 | |a RESULTS: Differences were found in early allograft dysfunction (68.1% in the SRR group vs 25% in the NRP group; P < .01) and biliary complications (22.7% vs 5%, respectively; P = .04). Differences were also found, although not statistically significant, in ischemic cholangiopathy (13.6% in the SRR group vs 5% in the NRP group; P = .09), and retransplant rate (9.1% vs 0%, respectively; P = .3) | ||
| 520 | |a CONCLUSIONS: With the use of NRP machines, results are similar to the standard donation with donors in brain death in terms of rate of early allograft dysfunction and survival of the patient and graft attempted, reducing the rate of ischemic cholangiopathy compared with SRR | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Martínez, María Pitarch |e verfasserin |4 aut | |
| 700 | 1 | |a León Díaz, Francisco Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández Aguilar, Jose Luis |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez Daga, Jose Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Santoyo, Julio |e verfasserin |4 aut | |
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