The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study) : Rationale and study design
Copyright © 2020 Hellenic Society of Cardiology. Published by Elsevier B.V. All rights reserved..
OBJECTIVE: Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. GRECCO-19 will be a prospective, randomized, open-labeled, controlled study to assess the effects of colchicine in COVID-19 complications prevention.
METHODS: Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2<95 mmHg will be included. Patients will be randomised (1:1) in colchicine or control group.
RESULTS: Trial results will be disseminated through peer-reviewed publications and conference presentations.
CONCLUSION: GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. (ClinicalTrials.gov Identifier: NCT04326790).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
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| Enthalten in: |
Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese - 61(2020), 1 vom: 02. Jan., Seite 42-45 |
| Sprache: |
Englisch |
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| Links: |
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| Themen: |
Antirheumatic Agents |
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| Anmerkungen: |
Date Completed 24.07.2020 Date Revised 28.03.2024 published: Print-Electronic ClinicalTrials.gov: NCT04326790 Citation Status MEDLINE |
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| doi: |
10.1016/j.hjc.2020.03.002 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM308370759 |
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| 100 | 1 | |a Deftereos, Spyridon G |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study) |b Rationale and study design |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 24.07.2020 | ||
| 500 | |a Date Revised 28.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT04326790 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Hellenic Society of Cardiology. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a OBJECTIVE: Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. GRECCO-19 will be a prospective, randomized, open-labeled, controlled study to assess the effects of colchicine in COVID-19 complications prevention | ||
| 520 | |a METHODS: Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2<95 mmHg will be included. Patients will be randomised (1:1) in colchicine or control group | ||
| 520 | |a RESULTS: Trial results will be disseminated through peer-reviewed publications and conference presentations | ||
| 520 | |a CONCLUSION: GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. (ClinicalTrials.gov Identifier: NCT04326790) | ||
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| 650 | 4 | |a Cardiac | |
| 650 | 4 | |a Complications | |
| 650 | 4 | |a Troponin | |
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| 650 | 7 | |a Troponin |2 NLM | |
| 650 | 7 | |a Colchicine |2 NLM | |
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| 700 | 1 | |a Siasos, Gerasimos |e verfasserin |4 aut | |
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| 700 | 1 | |a Vrachatis, Dimitrios A |e verfasserin |4 aut | |
| 700 | 1 | |a Angelidis, Christos |e verfasserin |4 aut | |
| 700 | 1 | |a Giotaki, Sotiria G |e verfasserin |4 aut | |
| 700 | 1 | |a Gargalianos, Panagiotis |e verfasserin |4 aut | |
| 700 | 1 | |a Giamarellou, Helen |e verfasserin |4 aut | |
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